BACKGROUND: In the present study, an activity of Bixa orellana extract against Leishmania amazonensis was demonstrated. RESULT: Experimentally infected BALB/c mice were treated with B. orellana extract which showed a significant activity against promastigote and amastigote forms of L. amazonensis. CONCLUSION: This study supports the importance of natural sources as antileishmanial drugs.
BACKGROUND: In the present study, an activity of Bixa orellana extract against Leishmania amazonensis was demonstrated. RESULT: Experimentally infected BALB/c mice were treated with B. orellana extract which showed a significant activity against promastigote and amastigote forms of L. amazonensis. CONCLUSION: This study supports the importance of natural sources as antileishmanial drugs.
Authors: Sergio Sifontes-Rodríguez; Lianet Monzote-Fidalgo; Nilo Castañedo-Cancio; Ana Margarita Montalvo-Álvarez; Yamilé López-Hernández; Niurka Mollineda Diogo; Juan Francisco Infante-Bourzac; Oliver Pérez-Martín; Alfredo Meneses-Marcel; José Antonio Escario García-Trevijano; Miguel Ángel Cabrera-Pérez Journal: Mem Inst Oswaldo Cruz Date: 2015-03-24 Impact factor: 2.743