| Literature DB >> 22189200 |
Laura Calabresi1, Sara Simonelli, Monica Gomaraschi, Guido Franceschini.
Abstract
The lecithin:cholesterol acyltransferase (LCAT) enzyme is responsible for the synthesis of cholesteryl esters in human plasma and plays a critical role in high density lipoprotein (HDL) metabolism. Genetic LCAT deficiency is a rare metabolic disorder characterized by low HDL cholesterol levels. This paper reviews the genetic and biochemical features of LCAT deficiency, highlighting the absence of enhanced preclinical atherosclerosis in carriers, despite the remarkably low HDL cholesterol.Entities:
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Year: 2011 PMID： 22189200 DOI： 10.1016/j.atherosclerosis.2011.11.034
Source DB: PubMed Journal: Atherosclerosis ISSN： 0021-9150 Impact factor: 5.162