| Literature DB >> 22189138 |
Charlotte A L Lane1, Duncan Hay, Charles E Mowbray, Michael Paradowski, Matthew D Selby, Nigel A Swain, David H Williams.
Abstract
This letter describes the discovery and synthesis of a series of octahydropyrrolo[3,4-c]pyrrole based selective histamine hH4 receptor antagonists. The amidine compound 20 was found to be a potent and selective histamine H4 receptor antagonist with moderate clearance and a high volume of distribution.Entities:
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Year: 2011 PMID： 22189138 DOI： 10.1016/j.bmcl.2011.11.098
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823