OBJECTIVES: To explore and quantify possible abnormalities in the autonomic cardiovascular regulation in presymptomatic stage of type 2 spinocerebellar ataxia (PS-SCA2). MATERIALS & METHODS: Heart rate variability (HRV) for 5-min series of RR intervals was analyzed in 48 PS-SCA2. Autonomic testing included resting recording, standing, Valsalva maneuver, and deep breathing. The results were compared with a group of sex- and age-matched controls. RESULTS: Time-and-frequency domain HRV indices were significantly different between PS-SCA2 and control groups. Using two standard diagnostic procedures were identified 4 (8.33%) subjects with severe and 8 (16.66%) subjects with early cardiac autonomic neuropathy in PS-SCA2. CAG index significantly correlated with age (-0.35) and HR (0.31). CONCLUSIONS: Our results confirm the presence of cardiovascular autonomic dysfunction in PS-SCA2 subjects.
OBJECTIVES: To explore and quantify possible abnormalities in the autonomic cardiovascular regulation in presymptomatic stage of type 2 spinocerebellar ataxia (PS-SCA2). MATERIALS & METHODS: Heart rate variability (HRV) for 5-min series of RR intervals was analyzed in 48 PS-SCA2. Autonomic testing included resting recording, standing, Valsalva maneuver, and deep breathing. The results were compared with a group of sex- and age-matched controls. RESULTS: Time-and-frequency domain HRV indices were significantly different between PS-SCA2 and control groups. Using two standard diagnostic procedures were identified 4 (8.33%) subjects with severe and 8 (16.66%) subjects with early cardiac autonomic neuropathy in PS-SCA2. CAG index significantly correlated with age (-0.35) and HR (0.31). CONCLUSIONS: Our results confirm the presence of cardiovascular autonomic dysfunction in PS-SCA2 subjects.
Authors: Elisabetta Indelicato; Alessandra Fanciulli; Jean Pierre Ndayisaba; Wolfgang Nachbauer; Roberta Granata; Julia Wanschitz; Michaela Wagner; Elke R Gizewski; Werner Poewe; Gregor K Wenning; Sylvia Boesch Journal: Clin Auton Res Date: 2018-02-12 Impact factor: 4.435
Authors: Elisabetta Indelicato; Alessandra Fanciulli; Jean-Pierre Ndayisaba; Wolfgang Nachbauer; Andreas Eigentler; Roberta Granata; Julia Wanschitz; Werner Poewe; Gregor K Wenning; Sylvia Boesch Journal: J Neurol Date: 2018-06-27 Impact factor: 4.849
Authors: Antonella Antenora; Carlo Rinaldi; Alessandro Roca; Chiara Pane; Maria Lieto; Francesco Saccà; Silvio Peluso; Giuseppe De Michele; Alessandro Filla Journal: Ann Clin Transl Neurol Date: 2017-08-10 Impact factor: 4.511