OBJECTIVES: To investigate whether problems in instrumental activities of daily living (IADL) can add to conventionally used clinical measurements in helping to predict a diagnosis of dementia at 1- and 2-year follow-up. DESIGN: Multicenter prospective cohort study. SETTING: Memory clinics in Europe. PARTICIPANTS: Individuals aged 55 and older without dementia. MEASUREMENTS: IADLs were measured using pooled activities from five informant-based questionnaires. Structural equation modeling (SEM) was used to investigate the relation between IADLs and dementia. Age, sex, education, depression, and cognitive measures (Mini-Mental State Examination and verbal memory) were included in the model. RESULTS: Five hundred thirty-one participants had baseline and 1-year follow-up assessments; 69 (13.0%) of these had developed dementia at 1-year follow-up. At 2-year follow-up, 481 participants were seen, of whom 100 (20.8%) had developed dementia. Participants with IADL disabilities at baseline had a higher conversion rate (24.4%) than participants without IADL disabilities (16.7%) (chi-square = 4.28, degrees of freedom = 1, P = .04). SEM showed that IADL disability could help predict dementia in addition to the measured variables at 1-year follow-up (odds ratio (OR) = 2.20, 95% confidence interval (CI) = 1.51-3.13) and 2-year follow-up (OR = 2.11, 95% CI = 1.33-3.33). CONCLUSION: IADL disability is a useful addition to the diagnostic process in a memory clinic setting, indicating who is at higher risk of developing dementia at 1- and 2-year follow-up.
OBJECTIVES: To investigate whether problems in instrumental activities of daily living (IADL) can add to conventionally used clinical measurements in helping to predict a diagnosis of dementia at 1- and 2-year follow-up. DESIGN: Multicenter prospective cohort study. SETTING: Memory clinics in Europe. PARTICIPANTS: Individuals aged 55 and older without dementia. MEASUREMENTS: IADLs were measured using pooled activities from five informant-based questionnaires. Structural equation modeling (SEM) was used to investigate the relation between IADLs and dementia. Age, sex, education, depression, and cognitive measures (Mini-Mental State Examination and verbal memory) were included in the model. RESULTS: Five hundred thirty-one participants had baseline and 1-year follow-up assessments; 69 (13.0%) of these had developed dementia at 1-year follow-up. At 2-year follow-up, 481 participants were seen, of whom 100 (20.8%) had developed dementia. Participants with IADL disabilities at baseline had a higher conversion rate (24.4%) than participants without IADL disabilities (16.7%) (chi-square = 4.28, degrees of freedom = 1, P = .04). SEM showed that IADL disability could help predict dementia in addition to the measured variables at 1-year follow-up (odds ratio (OR) = 2.20, 95% confidence interval (CI) = 1.51-3.13) and 2-year follow-up (OR = 2.11, 95% CI = 1.33-3.33). CONCLUSION:IADL disability is a useful addition to the diagnostic process in a memory clinic setting, indicating who is at higher risk of developing dementia at 1- and 2-year follow-up.
Authors: Nathan E Brummel; Susan P Bell; Timothy D Girard; Pratik P Pandharipande; James C Jackson; Alessandro Morandi; Jennifer L Thompson; Rameela Chandrasekhar; Gordon R Bernard; Robert S Dittus; Thomas M Gill; E Wesley Ely Journal: Am J Respir Crit Care Med Date: 2017-07-01 Impact factor: 21.405
Authors: Alberto Costa; Thomas Bak; Paolo Caffarra; Carlo Caltagirone; Mathieu Ceccaldi; Fabienne Collette; Sebastian Crutch; Sergio Della Sala; Jean François Démonet; Bruno Dubois; Emrah Duzel; Peter Nestor; Sokratis G Papageorgiou; Eric Salmon; Sietske Sikkes; Pietro Tiraboschi; Wiesje M van der Flier; Pieter Jelle Visser; Stefano F Cappa Journal: Alzheimers Res Ther Date: 2017-04-17 Impact factor: 6.982
Authors: Sandra Weintraub; Maria C Carrillo; Sarah Tomaszewski Farias; Terry E Goldberg; James A Hendrix; Judith Jaeger; David S Knopman; Jessica B Langbaum; Denise C Park; Michael T Ropacki; Sietske A M Sikkes; Kathleen A Welsh-Bohmer; Lisa J Bain; Robert Brashear; Kumar Budur; Ana Graf; Ferenc Martenyi; Marta Segardahl Storck; Christopher Randolph Journal: Alzheimers Dement (N Y) Date: 2018-02-13
Authors: Ingrid S van Maurik; Rosalinde E R Slot; Sander C J Verfaillie; Marissa D Zwan; Femke H Bouwman; Niels D Prins; Charlotte E Teunissen; Philip Scheltens; Frederik Barkhof; Mike P Wattjes; Jose Luis Molinuevo; Lorena Rami; Steffen Wolfsgruber; Oliver Peters; Frank Jessen; Johannes Berkhof; Wiesje M van der Flier Journal: Alzheimers Res Ther Date: 2019-04-16 Impact factor: 6.982
Authors: Michael L Alosco; Mary Beth Spitznagel; Ronald Cohen; Lawrence H Sweet; Lisa H Colbert; Richard Josephson; Joel Hughes; Jim Rosneck; John Gunstad Journal: Eur J Cardiovasc Nurs Date: 2013-06-09 Impact factor: 3.908