Literature DB >> 22186085

Is RORγ a therapeutic target for treating Mycobacterium tuberculosis infections?

Paul W Baures1.   

Abstract

A link is hypothesized between inhibition of the retinoic acid receptor-related orphan receptor γ (RORγ) and treatment of Mycobacterium tuberculosis (Mtb) infection. An unexpected overlap was found between inhibitors of both Mtb H37Rv with RORγ in PubChem. Since RORγ is not present in Mtb, a commonality was reasoned to be cholesterol. Gemfibrozil is a RORγ inhibitor that was inactive against Mtb cells. Yet, gemfibrozil has been shown to inhibit Mtb growth in macrophages, supporting the hypothesis that RORγ inhibitors could show therapeutic benefit in Mtb infection.(7).
Copyright © 2011 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID： 22186085     DOI： 10.1016/j.tube.2011.11.009

Source DB:  PubMed          Journal:  Tuberculosis (Edinb)        ISSN： 1472-9792            Impact factor:   3.131


  3 in total

1.  Interleukin-17A as a Biomarker for Bovine Tuberculosis.

Authors:  W Ray Waters; Mayara F Maggioli; Mitchell V Palmer; Tyler C Thacker; Jodi L McGill; H Martin Vordermeier; Linda Berney-Meyer; William R Jacobs; Michelle H Larsen
Journal:  Clin Vaccine Immunol       Date:  2015-12-16

2.  Normalization of the levels of inflammatory molecules in Mycobacterium smegmatis-infected U937 cells by fibrate pretreatment.

Authors:  Sung-Jo Kim; Minho Hong; Ki Duk Song; Hak-Kyo Lee; Sungweon Ryoo; Tae-Hwe Heo
Journal:  Biol Res       Date:  2014-09-15       Impact factor: 5.612

3.  Fenofibrate Facilitates Post-Active Tuberculosis Infection in Macrophages and is Associated with Higher Mortality in Patients under Long-Term Treatment.

Authors:  Ching-Lung Liu; Yen-Ta Lu; I-Fan Tsai; Ling-Chiao Wu; Wu-Chien Chien; Chi-Hsiang Chung; Kuo-Hsing Ma
Journal:  J Clin Med       Date:  2020-01-25       Impact factor: 4.241
  3 in total

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