Literature DB >> 22185644

Recurrent neck abscesses due to cervical tuberculous lymphadenopathy in an elderly woman post-splenectomy: a case report.

Aaron L Niblock1.   

Abstract

INTRODUCTION: There are approximately 7000 new cases of tuberculosis every year in the UK, the majority of which are pulmonary. Approximately 5% affect the lymph nodes in immunocompetent patients. Scrofula is an old term used to describe lymph nodes of the neck infected with tuberculosis CASE
PRESENTATION: In the elderly population, growing neck lumps are always treated as red flags until a diagnosis is confirmed. Here, the case of an 89-year-old Caucasian woman is presented. She was reluctant to seek medical help as she feared the cause was sinister and did not want surgical intervention.
CONCLUSION: It is difficult to culture tuberculosis from superficial swabs, resulting in a high proportion of false negative results. Where there is a high degree of clinical suspicion for tuberculosis, it is important to consider a biopsy with culture. Patients over the age of 65 have waning immunity and are therefore a vulnerable group for acute infections as well as the re-activation of indolent organisms. Post-splenectomy patients are at a major disadvantage during sepsis and when a cellular immune response is required, such as when faced with a Mycobacterium tuberculosis infection. Scrofula is treated with a similar regime as pulmonary tuberculosis and has a near 100% success rate.

Entities:  

Year:  2011        PMID: 22185644      PMCID: PMC3284562          DOI: 10.1186/1752-1947-5-584

Source DB:  PubMed          Journal:  J Med Case Rep        ISSN: 1752-1947


  11 in total

1.  Aging affects initiation and continuation of T cell proliferation.

Authors:  Jiu Jiang; Diara Gross; Philip Elbaum; Donna M Murasko
Journal:  Mech Ageing Dev       Date:  2007-02-23       Impact factor: 5.432

Review 2.  The host immune response to tuberculosis.

Authors:  N W Schluger; W N Rom
Journal:  Am J Respir Crit Care Med       Date:  1998-03       Impact factor: 21.405

3.  Effects of splenectomy on the humoral immune system. A study in neonatally and adult splenectomized mice.

Authors:  J Rozing; N H Brons; R Bennner
Journal:  Immunology       Date:  1978-05       Impact factor: 7.397

Review 4.  Tuberculosis at extremes of age.

Authors:  H Simon Schaaf; Andrea Collins; Adrie Bekker; Peter D O Davies
Journal:  Respirology       Date:  2010-06-04       Impact factor: 6.424

Review 5.  Roles of cytotoxic delayed-type hypersensitivity and macrophage-activating cell-mediated immunity in the pathogenesis of tuberculosis.

Authors:  A M Dannenberg
Journal:  Immunobiology       Date:  1994-10       Impact factor: 3.144

Review 6.  Extrapulmonary tuberculosis.

Authors:  S K Sharma; A Mohan
Journal:  Indian J Med Res       Date:  2004-10       Impact factor: 2.375

7.  The effect of ageing on human lymphocyte subsets: comparison of males and females.

Authors:  Jun Yan; Judith M Greer; Renee Hull; John D O'Sullivan; Robert D Henderson; Stephen J Read; Pamela A McCombe
Journal:  Immun Ageing       Date:  2010-03-16       Impact factor: 6.400

Review 8.  How B cells shape the immune response against Mycobacterium tuberculosis.

Authors:  Paul J Maglione; John Chan
Journal:  Eur J Immunol       Date:  2009-03       Impact factor: 5.532

9.  Clinical differences between pulmonary and extrapulmonary tuberculosis: a 5-year retrospective study.

Authors:  S J Antony; V Harrell; J D Christie; H G Adams; R L Rumley
Journal:  J Natl Med Assoc       Date:  1995-03       Impact factor: 1.798

Review 10.  Host innate immune response to Mycobacterium tuberculosis.

Authors:  Kamlesh Bhatt; Padmini Salgame
Journal:  J Clin Immunol       Date:  2007-03-16       Impact factor: 8.542

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