PURPOSE: To evaluate progression pattern and progression-free interval for patients with glioblastoma multiforme (GBM), on the basis of the extent of resection. MATERIALS AND METHODS: Between January 2000 and September 2009, 138 patients with GBM underwent postoperative radiation therapy and longitudinal magnetic resonance imaging studies. The operations were classified as biopsy, partial resection (PR), and gross total resection (GTR). Progression patterns were classified as gross tumor volume (GTV), T2 hyperintensity (T2h), distant, and free. We used the Kruskal-Wallis test to compare progression-free intervals on the basis of the extent of resection and the progression pattern. RESULTS: Recurrence of biopsied and PR tumors at the GTV site was 100 and 97%, respectively. The median progression-free interval was 3 months for biopsied (n = 29), 4 months for PR (n = 70), and 8 months for GTR (n = 39) tumors (p < 0.05). The median progression-free interval for progression patterns classified as GTV (n = 97), T2h (n = 24), distant (n = 12), and free (n = 5) was 3 (p < 0.05), 7, 8, and 29 months, respectively. CONCLUSION: Control of the GTV can increase the progression-free interval because gross residual tumors progress earlier than infiltrating tumor cells do.
PURPOSE: To evaluate progression pattern and progression-free interval for patients with glioblastoma multiforme (GBM), on the basis of the extent of resection. MATERIALS AND METHODS: Between January 2000 and September 2009, 138 patients with GBM underwent postoperative radiation therapy and longitudinal magnetic resonance imaging studies. The operations were classified as biopsy, partial resection (PR), and gross total resection (GTR). Progression patterns were classified as gross tumor volume (GTV), T2 hyperintensity (T2h), distant, and free. We used the Kruskal-Wallis test to compare progression-free intervals on the basis of the extent of resection and the progression pattern. RESULTS: Recurrence of biopsied and PR tumors at the GTV site was 100 and 97%, respectively. The median progression-free interval was 3 months for biopsied (n = 29), 4 months for PR (n = 70), and 8 months for GTR (n = 39) tumors (p < 0.05). The median progression-free interval for progression patterns classified as GTV (n = 97), T2h (n = 24), distant (n = 12), and free (n = 5) was 3 (p < 0.05), 7, 8, and 29 months, respectively. CONCLUSION: Control of the GTV can increase the progression-free interval because gross residual tumors progress earlier than infiltrating tumor cells do.
Authors: Eric L Chang; Serap Akyurek; Tedde Avalos; Neal Rebueno; Chris Spicer; John Garcia; Robin Famiglietti; Pamela K Allen; K S Clifford Chao; Anita Mahajan; Shiao Y Woo; Moshe H Maor Journal: Int J Radiat Oncol Biol Phys Date: 2007-02-15 Impact factor: 7.038
Authors: June L Chan; Susan W Lee; Benedick A Fraass; Daniel P Normolle; Harry S Greenberg; Larry R Junck; Stephen S Gebarski; Howard M Sandler Journal: J Clin Oncol Date: 2002-03-15 Impact factor: 44.544
Authors: W J Curran; C B Scott; J Horton; J S Nelson; A S Weinstein; A J Fischbach; C H Chang; M Rotman; S O Asbell; R E Krisch Journal: J Natl Cancer Inst Date: 1993-05-05 Impact factor: 13.506
Authors: Roger Stupp; Monika E Hegi; Warren P Mason; Martin J van den Bent; Martin J B Taphoorn; Robert C Janzer; Samuel K Ludwin; Anouk Allgeier; Barbara Fisher; Karl Belanger; Peter Hau; Alba A Brandes; Johanna Gijtenbeek; Christine Marosi; Charles J Vecht; Karima Mokhtari; Pieter Wesseling; Salvador Villa; Elizabeth Eisenhauer; Thierry Gorlia; Michael Weller; Denis Lacombe; J Gregory Cairncross; René-Olivier Mirimanoff Journal: Lancet Oncol Date: 2009-03-09 Impact factor: 41.316
Authors: Stephanie E Combs; Johanna Wagner; Marc Bischof; Thomas Welzel; Florian Wagner; Jürgen Debus; Daniela Schulz-Ertner Journal: Int J Radiat Oncol Biol Phys Date: 2007-10-29 Impact factor: 7.038