Literature DB >> 22182836

Epoxyeicosatrienoic acids: a double-edged sword in cardiovascular diseases and cancer.

Dingzhi Wang1, Raymond N Dubois.   

Abstract

Epoxyeicosatrienoic acids (EETs) generated from arachidonic acid by cytochrome P450 (CYP) epoxygenases have beneficial effects in certain cardiovascular and kidney diseases. Hence, great efforts have been made to develop drugs targeting the EET pathway. Some of these agents are currently under evaluation in clinical trials for treatment of hypertension and diabetes. In this issue of the JCI, Panigrahy et al. evaluate in a systematic way the role of CYP epoxygenases and the metabolites they generate in cancer progression. Their findings, along with previous studies, raise concerns about using these drugs in humans.

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Year:  2011        PMID： 22182836      PMCID： PMC3248310          DOI： 10.1172/JCI61453

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  22 in total

1.  14,15-Dihydroxyeicosatrienoic acid activates peroxisome proliferator-activated receptor-alpha.

Authors:  Xiang Fang; Shanming Hu; Bingkun Xu; Gary D Snyder; Shawn Harmon; Jianrong Yao; Yi Liu; Bhavani Sangras; J R Falck; Neal L Weintraub; Arthur A Spector
Journal:  Am J Physiol Heart Circ Physiol       Date:  2005-08-19       Impact factor: 4.733

2.  Cytochrome P450 epoxygenases 2C8 and 2C9 are implicated in hypoxia-induced endothelial cell migration and angiogenesis.

Authors:  U Ruth Michaelis; Beate Fisslthaler; Eduardo Barbosa-Sicard; John R Falck; Ingrid Fleming; Rudi Busse
Journal:  J Cell Sci       Date:  2005-11-15       Impact factor: 5.285

3.  Cytochrome P450 2J2 promotes the neoplastic phenotype of carcinoma cells and is up-regulated in human tumors.

Authors:  Jian-Gang Jiang; Chun-Lian Chen; Jeffrey W Card; Shilin Yang; Ji-Xiong Chen; Xiang-Ning Fu; Yao-Gui Ning; Xiao Xiao; Darryl C Zeldin; Dao Wen Wang
Journal:  Cancer Res       Date:  2005-06-01       Impact factor: 12.701

4.  Characterization of 14,15-epoxyeicosatrienoyl-sulfonamides as 14,15-epoxyeicosatrienoic acid agonists: use for studies of metabolism and ligand binding.

Authors:  Wenqi Yang; Blythe B Holmes; V Raj Gopal; R V Krishna Kishore; Bhavani Sangras; Xiu-Yu Yi; J R Falck; William B Campbell
Journal:  J Pharmacol Exp Ther       Date:  2007-02-27       Impact factor: 4.030

5.  The antiinflammatory effect of laminar flow: the role of PPARgamma, epoxyeicosatrienoic acids, and soluble epoxide hydrolase.

Authors:  Yi Liu; Yingjia Zhang; Kara Schmelzer; Tzong-Shyuan Lee; Xiang Fang; Yi Zhu; Arthur A Spector; Sarjeet Gill; Christophe Morisseau; Bruce D Hammock; John Y-J Shyy
Journal:  Proc Natl Acad Sci U S A       Date:  2005-11-02       Impact factor: 11.205

Review 6.  Vascular cytochrome p450 enzymes: physiology and pathophysiology.

Authors:  Ingrid Fleming
Journal:  Trends Cardiovasc Med       Date:  2008-01       Impact factor: 6.677

7.  Selective inhibitors of CYP2J2 related to terfenadine exhibit strong activity against human cancers in vitro and in vivo.

Authors:  Chen Chen; Guiling Li; Wanmin Liao; Jun Wu; Liu Liu; Ding Ma; Jianfeng Zhou; Reem H Elbekai; Matthew L Edin; Darryl C Zeldin; Dao Wen Wang
Journal:  J Pharmacol Exp Ther       Date:  2009-03-16       Impact factor: 4.030

8.  Effect of 11,12-epoxyeicosatrienoic acid as an additive to St. Thomas' cardioplegia and University of Wisconsin solutions on endothelium-derived hyperpolarizing factor-mediated function in coronary microarteries: influence of temperature and time.

Authors:  Qin Yang; Rong-Zhen Zhang; Anthony P C Yim; Guo-Wei He
Journal:  Ann Thorac Surg       Date:  2003-11       Impact factor: 4.330

9.  Cytochrome p450 epoxygenase promotes human cancer metastasis.

Authors:  Jian-Gang Jiang; Yao-Gui Ning; Chen Chen; Ding Ma; Zhen-Jun Liu; Shilin Yang; Jianfeng Zhou; Xiao Xiao; Xin A Zhang; Matthew L Edin; Jeffrey W Card; Jianing Wang; Darryl C Zeldin; Dao Wen Wang
Journal:  Cancer Res       Date:  2007-07-15       Impact factor: 12.701

10.  Antigenic stimulation with cytochrome P450 2J expressed in mouse hepatocellular carcinoma cells regulates host anti-tumour immunity.

Authors:  S Homma; S Koido; Y Sagawa; H Suzuki; H Komita; E Nagasaki; A Takahara; J Horiguchi-Yamada; H Tajiri; D C Zeldin; T Obata
Journal:  Clin Exp Immunol       Date:  2009-03-02       Impact factor: 4.330
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  23 in total

1.  Addition of DHA Synergistically Enhances the Efficacy of Regorafenib for Kidney Cancer Therapy.

Authors:  Jeffrey Kim; Arzu Ulu; Debin Wan; Jun Yang; Bruce D Hammock; Robert H Weiss
Journal:  Mol Cancer Ther       Date:  2016-02-26       Impact factor: 6.261

2.  EPA and/or DHA? A test question on the principles and opportunities in utilizing the therapeutic potential of omega-3 fatty acids.

Authors:  Wolf-Hagen Schunck
Journal:  J Lipid Res       Date:  2016-07-19       Impact factor: 5.922

3.  Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria.

Authors:  Zhijun Guo; Irina F Sevrioukova; Ilia G Denisov; Xia Zhang; Ting-Lan Chiu; Dafydd G Thomas; Eric A Hanse; Rebecca A D Cuellar; Yelena V Grinkova; Vanessa Wankhede Langenfeld; Daniel S Swedien; Justin D Stamschror; Juan Alvarez; Fernando Luna; Adela Galván; Young Kyung Bae; Julia D Wulfkuhle; Rosa I Gallagher; Emanuel F Petricoin; Beverly Norris; Craig M Flory; Robert J Schumacher; M Gerard O'Sullivan; Qing Cao; Haitao Chu; John D Lipscomb; William M Atkins; Kalpna Gupta; Ameeta Kelekar; Ian A Blair; Jorge H Capdevila; John R Falck; Stephen G Sligar; Thomas L Poulos; Gunda I Georg; Elizabeth Ambrose; David A Potter
Journal:  Cell Chem Biol       Date:  2017-09-14       Impact factor: 8.116

4.  Cytochrome P450 monooxygenase lipid metabolites are significant second messengers in the resolution of choroidal neovascularization.

Authors:  Eiichi Hasegawa; Saori Inafuku; Lama Mulki; Yoko Okunuki; Ryoji Yanai; Kaylee E Smith; Clifford B Kim; Garrett Klokman; Diane R Bielenberg; Narender Puli; John R Falck; Deeba Husain; Joan W Miller; Matthew L Edin; Darryl C Zeldin; Kin Sing Stephen Lee; Bruce D Hammock; Wolf-Hagen Schunck; Kip M Connor
Journal:  Proc Natl Acad Sci U S A       Date:  2017-08-21       Impact factor: 11.205

5.  Peripheral soluble epoxide hydrolase inhibition reduces hypernociception and inflammation in albumin-induced arthritis in temporomandibular joint of rats.

Authors:  Juliana Maia Teixeira; Henrique Ballassini Abdalla; Rosanna Tarkany Basting; Bruce D Hammock; Marcelo Henrique Napimoga; Juliana Trindade Clemente-Napimoga
Journal:  Int Immunopharmacol       Date:  2020-07-28       Impact factor: 4.932

Review 6.  Epoxyeicosatrienoic acids and cardioprotection: the road to translation.

Authors:  Akinyemi Oni-Orisan; Nasser Alsaleh; Craig R Lee; John M Seubert
Journal:  J Mol Cell Cardiol       Date:  2014-06-02       Impact factor: 5.000

7.  Inhibition of Soluble Epoxide Hydrolase 2 Ameliorates Diabetic Keratopathy and Impaired Wound Healing in Mouse Corneas.

Authors:  Haijing Sun; Patrick Lee; Chenxi Yan; Nan Gao; Jiemei Wang; Xianqun Fan; Fu-Shin Yu
Journal:  Diabetes       Date:  2018-04-03       Impact factor: 9.461

8.  Cytochrome P450-generated metabolites derived from ω-3 fatty acids attenuate neovascularization.

Authors:  Ryoji Yanai; Lama Mulki; Eiichi Hasegawa; Kimio Takeuchi; Harry Sweigard; Jun Suzuki; Philipp Gaissert; Demetrios G Vavvas; Koh-Hei Sonoda; Michael Rothe; Wolf-Hagen Schunck; Joan W Miller; Kip M Connor
Journal:  Proc Natl Acad Sci U S A       Date:  2014-06-16       Impact factor: 11.205

9.  A sensitive and improved throughput UPLC-MS/MS quantitation method of total cytochrome P450 mediated arachidonic acid metabolites that can separate regio-isomers and cis/trans-EETs from human plasma.

Authors:  Maxwell Zeigler; Dale Whittington; Nona Sotoodehnia; Rozenn N Lemaitre; Rheem A Totah
Journal:  Chem Phys Lipids       Date:  2018-09-07       Impact factor: 3.329

Review 10.  Role of Arachidonic Acid and Its Metabolites in the Biological and Clinical Manifestations of Idiopathic Nephrotic Syndrome.

Authors:  Stefano Turolo; Alberto Edefonti; Alessandra Mazzocchi; Marie Louise Syren; William Morello; Carlo Agostoni; Giovanni Montini
Journal:  Int J Mol Sci       Date:  2021-05-21       Impact factor: 5.923
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