| Literature DB >> 22182585 |
Rong Wen1, Weng Tao, Yiwen Li, Paul A Sieving.
Abstract
Ciliary neurotrophic factor (CNTF) is one of the most studied neurotrophic factors for neuroprotection of the retina. A large body of evidence demonstrates that CNTF promotes rod photoreceptor survival in almost all animal models. Recent studies indicate that CNTF also promotes cone photoreceptor survival and cone outer segment regeneration in the degenerating retina and improves cone function in dogs with congenital achromotopsia. In addition, CNTF is a neuroprotective factor and an axogenesis factor for retinal ganglion cells (RGCs). This review focuses on the effects of exogenous CNTF on photoreceptors and RGCs in the mammalian retina and the potential clinical application of CNTF for retinal degenerative diseases.Entities:
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Year: 2011 PMID: 22182585 PMCID: PMC3288688 DOI: 10.1016/j.preteyeres.2011.11.005
Source DB: PubMed Journal: Prog Retin Eye Res ISSN: 1350-9462 Impact factor: 21.198