Literature DB >> 22181015

New bicyclo[3.1.0]hexane unit ent-kaurane diterpene and its seco-derivative from Isodon eriocalyx var. laxiflora.

Wei-Guang Wang1, Xue Du, Xiao-Nian Li, Hai-Yan Wu, Xu Liu, Shan-Zhai Shang, Rui Zhan, Cheng-Qin Liang, Ling-Mei Kong, Yan Li, Jian-Xin Pu, Han-Dong Sun.   

Abstract

Neolaxiflorin A (1), an unprecedented ent-kaurane diterpenoid with a bicyclo[3.1.0]hexane unit, and its seco-derivative, neolaxiflorin B (2), along with two known compounds 3 and 4 were isolated from the leaves of Isodon eriocalyx var. laxiflora. The absolute configuration of 1 was determined by spectral methods and single crystal X-ray diffraction analysis. Compound 4 and the synthesized compound 5 exhibited significant cytotoxicity.
© 2011 American Chemical Society

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Year:  2011        PMID： 22181015     DOI： 10.1021/ol203061z

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  6 in total

1.  Longikaurin E induces apoptosis of pancreatic cancer cells via modulation of the p38 and PI3K/AKT pathways by ROS.

Authors:  Hai-bo Cheng; Yun Bo; Wei-xing Shen; Xian-guo Ren; Jia-ni Tan; Zhi-rong Jia; Chang-Liang Xu
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2015-03-06       Impact factor: 3.000

2.  Longikaurin A, a natural ent-kaurane, induces G2/M phase arrest via downregulation of Skp2 and apoptosis induction through ROS/JNK/c-Jun pathway in hepatocellular carcinoma cells.

Authors:  Y-J Liao; H-Y Bai; Z-H Li; J Zou; J-W Chen; F Zheng; J-X Zhang; S-J Mai; M-S Zeng; H-D Sun; J-X Pu; D Xie
Journal:  Cell Death Dis       Date:  2014-03-20       Impact factor: 8.469

3.  Fimbriatols A-J, Highly Oxidized ent-Kaurane Diterpenoids from Traditional Chinese Plant Flickingeria fimbriata (B1.) Hawkes.

Authors:  Gang Ding; Jiaodong Fei; Jing Wang; Yong Xie; Rongtao Li; Ningbo Gong; Yang Lv; Changyuan Yu; Zhongmei Zou
Journal:  Sci Rep       Date:  2016-08-03       Impact factor: 4.379

Review 4.  Harvest, After 50 Years of Sowing.

Authors:  Pema-Tenzin Puno
Journal:  Nat Prod Bioprospect       Date:  2018-07-19

5.  Synthesis and antitumor evaluation of neolaxiflorin B inspired compounds.

Authors:  Jing-Ping Liu; Ye-Zhi Xiao; Yu Hu; Xiao-Nian Li; Ming-Jiang Wu; Yong Zhao; Yan Zhao; Ze-Jin Ma; Jing Shen
Journal:  Drug Des Devel Ther       Date:  2019-08-23       Impact factor: 4.162

Review 6.  Oridonin, a Promising ent-Kaurane Diterpenoid Lead Compound.

Authors:  Dahong Li; Tong Han; Jie Liao; Xu Hu; Shengtao Xu; Kangtao Tian; Xiaoke Gu; Keguang Cheng; Zhanlin Li; Huiming Hua; Jinyi Xu
Journal:  Int J Mol Sci       Date:  2016-08-24       Impact factor: 5.923
  6 in total

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