Literature DB >> 22180829

The role of SIRT1 in tumorigenesis.

Kai Li1, Jianyuan Luo.   

Abstract

NAD-dependent Class III histone deacetylase SIRT1 is a multiple functional protein and has been demonstrated critically involved in stress response, cellular metabolism and aging through deacetylating variety of substrates including p53, forkhead transcription factors, PGC-1α, NF-κB, Ku70 and histones. Increasing evidences indicate that SIRT1 plays a complex role in tumorigenesis with functions in both tumor promoting and tumor suppressing. This review provides an overview of current knowledge of SIRT1 and its controversies regarding the functions of SIRT1 in tumorigenesis.

Entities:  

Year:  2011        PMID： 22180829      PMCID： PMC3237400          DOI： 10.7156/v4i2p104

Source DB:  PubMed          Journal:  N Am J Med Sci (Boston)        ISSN： 1946-9357


  46 in total

1.  Direct coupling of the cell cycle and cell death machinery by E2F.

Authors:  Zaher Nahle; Julia Polakoff; Ramana V Davuluri; Mila E McCurrach; Matthew D Jacobson; Masashi Narita; Michael Q Zhang; Yuri Lazebnik; Dafna Bar-Sagi; Scott W Lowe
Journal:  Nat Cell Biol       Date:  2002-11       Impact factor: 28.824

2.  SIRT1 regulates UV-induced DNA repair through deacetylating XPA.

Authors:  Wei Fan; Jianyuan Luo
Journal:  Mol Cell       Date:  2010-07-30       Impact factor: 17.970

3.  The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms.

Authors:  M Kaeberlein; M McVey; L Guarente
Journal:  Genes Dev       Date:  1999-10-01       Impact factor: 11.361

4.  Negative control of p53 by Sir2alpha promotes cell survival under stress.

Authors:  J Luo; A Y Nikolaev; S Imai; D Chen; F Su; A Shiloh; L Guarente; W Gu
Journal:  Cell       Date:  2001-10-19       Impact factor: 41.582

5.  Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction.

Authors:  Dena E Cohen; Andrea M Supinski; Michael S Bonkowski; Gizem Donmez; Leonard P Guarente
Journal:  Genes Dev       Date:  2009-12-15       Impact factor: 11.361

6.  Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase.

Authors:  Anne Brunet; Lora B Sweeney; J Fitzhugh Sturgill; Katrin F Chua; Paul L Greer; Yingxi Lin; Hien Tran; Sarah E Ross; Raul Mostoslavsky; Haim Y Cohen; Linda S Hu; Hwei-Ling Cheng; Mark P Jedrychowski; Steven P Gygi; David A Sinclair; Frederick W Alt; Michael E Greenberg
Journal:  Science       Date:  2004-02-19       Impact factor: 47.728

Review 7.  Survivin, cancer networks and pathway-directed drug discovery.

Authors:  Dario C Altieri
Journal:  Nat Rev Cancer       Date:  2008-01       Impact factor: 60.716

8.  Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice.

Authors:  Rui-Hong Wang; Kundan Sengupta; Cuiling Li; Hyun-Seok Kim; Liu Cao; Cuiying Xiao; Sangsoo Kim; Xiaoling Xu; Yin Zheng; Beverly Chilton; Rong Jia; Zhi-Ming Zheng; Ettore Appella; Xin Wei Wang; Thomas Ried; Chu-Xia Deng
Journal:  Cancer Cell       Date:  2008-10-07       Impact factor: 31.743

9.  SIRT1 is significantly elevated in mouse and human prostate cancer.

Authors:  Derek M Huffman; William E Grizzle; Marcas M Bamman; Jeong-su Kim; Isam A Eltoum; Ada Elgavish; Tim R Nagy
Journal:  Cancer Res       Date:  2007-07-15       Impact factor: 12.701

10.  Mammalian SIRT1 represses forkhead transcription factors.

Authors:  Maria Carla Motta; Nullin Divecha; Madeleine Lemieux; Christopher Kamel; Delin Chen; Wei Gu; Yvette Bultsma; Michael McBurney; Leonard Guarente
Journal:  Cell       Date:  2004-02-20       Impact factor: 41.582
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  17 in total

1.  Bisindole-PBD regulates breast cancer cell proliferation via SIRT-p53 axis.

Authors:  Pranjal Sarma; Indira Bag; M Janaki Ramaiah; Ahmed Kamal; Utpal Bhadra; Manika Pal Bhadra
Journal:  Cancer Biol Ther       Date:  2015-07-20       Impact factor: 4.742

Review 2.  SIRT1 Expression Is a Promising Prognostic Biomarker in Esophageal Squamous Cell Carcinoma: A Systematic Review and Meta-analysis.

Authors:  Ryota Otsuka; Haruhito Sakata; Kentaro Murakami; Masayuki Kano; Satoshi Endo; Takeshi Toyozumi; Yasunori Matsumoto; Hiroshi Suito; Masahiko Takahashi; Nobufumi Sekino; Soichiro Hirasawa; Kazuya Kinoshita; Takuma Sasaki; Hisahiro Matsubara
Journal:  Cancer Diagn Progn       Date:  2022-03-03

Review 3.  Carcinoma of the gastroesophageal junction in Chinese patients.

Authors:  Qin Huang
Journal:  World J Gastroenterol       Date:  2012-12-28       Impact factor: 5.742

4.  Analysis of 41 cancer cell lines reveals excessive allelic loss and novel mutations in the SIRT1 gene.

Authors:  Jeehae Han; Basil P Hubbard; Jaehoon Lee; Cristina Montagna; Han-Woong Lee; David A Sinclair; Yousin Suh
Journal:  Cell Cycle       Date:  2012-01-15       Impact factor: 4.534

Review 5.  Chemical metabolic inhibitors for the treatment of blood-borne cancers.

Authors:  Martin Villalba; Nuria Lopez-Royuela; Ewelina Krzywinska; Moeez G Rathore; Robert A Hipskind; Houda Haouas; Nerea Allende-Vega
Journal:  Anticancer Agents Med Chem       Date:  2014-02       Impact factor: 2.505

6.  The SIRT1/TP53 axis is activated upon B-cell receptor triggering via miR-132 up-regulation in chronic lymphocytic leukemia cells.

Authors:  Michele Dal Bo; Tiziana D'Agaro; Stefania Gobessi; Antonella Zucchetto; Sara Dereani; Davide Rossi; Francesco Zaja; Gabriele Pozzato; Francesco Di Raimondo; Gianluca Gaidano; Luca Laurenti; Giovanni Del Poeta; Dimitar G Efremov; Valter Gattei; Riccardo Bomben
Journal:  Oncotarget       Date:  2015-08-07

7.  Post-translational regulation contributes to the loss of LKB1 expression through SIRT1 deacetylase in osteosarcomas.

Authors:  Nadège Presneau; Laure Alice Duhamel; Hongtao Ye; Roberto Tirabosco; Adrienne M Flanagan; Malihe Eskandarpour
Journal:  Br J Cancer       Date:  2017-06-20       Impact factor: 7.640

8.  Histone deacetylase inhibition: an important mechanism in the treatment of lymphoma.

Authors:  Shan-Qi Guo; Yi-Zhuo Zhang
Journal:  Cancer Biol Med       Date:  2012-06       Impact factor: 4.248

9.  Down-regulation of mir-221 and mir-222 restrain prostate cancer cell proliferation and migration that is partly mediated by activation of SIRT1.

Authors:  Xiao Yang; Yingmei Yang; Rong Gan; Lingxu Zhao; Wei Li; Huaibin Zhou; Xiaojuan Wang; Jianxin Lu; Qing H Meng
Journal:  PLoS One       Date:  2014-06-03       Impact factor: 3.240

10.  Association between SIRT1 Gene Polymorphisms and Breast Cancer in Egyptians.

Authors:  Sherine M Rizk; Nancy N Shahin; Olfat G Shaker
Journal:  PLoS One       Date:  2016-03-21       Impact factor: 3.240
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