Literature DB >> 2218073

In vitro interaction of mercury, copper (II) and cadmium with human glutathione transferase pi.

M M Almar1, P J Dierickx.   

Abstract

The in vitro interaction of mercury, copper (II) and cadmium with human glutathione transferase (GST) pi was studied using reduced glutathione (GSH) and 1-chloro-2,4-dinitrobenzene as substrate. Tumor specific human GST pi was isolated from the human hepatoma derived PLC/PRF/5 cell line. The inhibition of the GST pi activity was dose dependent. Kinetic studies never revealed competitive inhibition. A parabolic inhibition was found with GSH as the variable substrate. The heavy metals are spontaneously conjugated with GSH and cysteine, but interact with GST pi by direct binding to this protein. This binding could have a protective function against heavy metals.

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Year:  1990        PMID： 2218073

Source DB:  PubMed          Journal:  Res Commun Chem Pathol Pharmacol        ISSN： 0034-5164


  7 in total

1.  Variants of glutathione s-transferase pi 1 exhibit differential enzymatic activity and inhibition by heavy metals.

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2.  Nucleotide Sequence of the Gene for a Glutathione S-Transferase from Cell Suspension Cultures of Silene cucubalus.

Authors:  R Prändl; T M Kutchan
Journal:  Plant Physiol       Date:  1992-08       Impact factor: 8.340

3.  Nucleotide Sequence of a cDNA Encoding a Constitutively Expressed Glutathione S-Transferase from Cell Suspension Cultures of Silene cucubalus.

Authors:  T M Kutchan; A Hochberger
Journal:  Plant Physiol       Date:  1992-06       Impact factor: 8.340

Review 4.  Role of cellular antioxidants in metal-induced damage.

Authors:  M Sugiyama
Journal:  Cell Biol Toxicol       Date:  1994-02       Impact factor: 6.691

5.  Effects of exposure to a mixture of cadmium and chromium on detoxification enzyme (GST, P450-MO) activities in the frog Rana ridibunda.

Authors:  Iason Kostaropoulos; Dimitra Kalmanti; Basiliki Theodoropoulou; Nikolaos S Loumbourdis
Journal:  Ecotoxicology       Date:  2005-05       Impact factor: 2.823

6.  Ultrastructural localization and chemical binding of silver ions in human organotypic skin cultures.

Authors:  Søren Kristiansen; Peter Ifversen; Gorm Danscher
Journal:  Histochem Cell Biol       Date:  2008-04-05       Impact factor: 4.304

7.  Genetic polymorphisms in glutathione (GSH-) related genes affect the plasmatic Hg/whole blood Hg partitioning and the distribution between inorganic and methylmercury levels in plasma collected from a fish-eating population.

Authors:  Andréia Ávila Soares de Oliveira; Marilesia Ferreira de Souza; André van Helvoort Lengert; Marcelo Tempesta de Oliveira; Rossana Batista de Oliveira Godoy Camargo; Gilberto Úbida Leite Braga; Ilce Mara de Syllos Cólus; Fernando Barbosa; Gustavo Rafael Mazzaron Barcelos
Journal:  Biomed Res Int       Date:  2014-02-18       Impact factor: 3.411
  7 in total

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