Literature DB >> 22180323

Redox-responsive molecular nanoreservoirs for controlled intracellular anticancer drug delivery based on magnetic nanoparticles.

Zhong Luo1, Kaiyong Cai, Yan Hu, Jinghua Li, Xingwei Ding, Beilu Zhang, Dawei Xu, Weihu Yang, Peng Liu.   

Abstract

A novel redox responsive controlled drug release system based on magnetic nanoparticles for efficient intracellular anticancer drug delivery is fabricated. Disulfide bonds are employed as intermediate linkers to immobilize PEI/β-CD molecules as nanoreservoirs for drug loading onto magnetic nanoparticles. The endocytotic pathway and endosomal escape of the smart controlled drug release system is proposed.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  endocytosis; endosomal escape; intracellular drug delivery; magnetic nanoparticles; redox response

Mesh：

Substances：

Year:  2011        PMID： 22180323     DOI： 10.1002/adma.201103458

Source DB:  PubMed          Journal:  Adv Mater        ISSN： 0935-9648            Impact factor:   30.849


  12 in total

1.  Recyclable heparin and chitosan conjugated magnetic nanocomposites for selective removal of low-density lipoprotein from plasma.

Authors:  Jinghua Li; Yanhua Hou; Xiuyong Chen; Xingwei Ding; Yun Liu; Xinkun Shen; Kaiyong Cai
Journal:  J Mater Sci Mater Med       Date:  2014-01-07       Impact factor: 3.896

2.  Pluronic F127 self-assembled MoS2 nanocomposites as an effective glutathione responsive anticancer drug delivery system.

Authors:  Adhisankar Vadivelmurugan; Rajeshkumar Anbazhagan; Vinothini Arunagiri; Juin-Yih Lai; Hsieh-Chih Tsai
Journal:  RSC Adv       Date:  2019-08-15       Impact factor: 4.036

Review 3.  Immunotoxins constructed with ribosome-inactivating proteins and their enhancers: a lethal cocktail with tumor specific efficacy.

Authors:  Roger Gilabert-Oriol; Alexander Weng; Benedicta von Mallinckrodt; Matthias F Melzig; Hendrik Fuchs; Mayank Thakur
Journal:  Curr Pharm Des       Date:  2014       Impact factor: 3.116

Review 4.  Contact-facilitated drug delivery with Sn2 lipase labile prodrugs optimize targeted lipid nanoparticle drug delivery.

Authors:  Dipanjan Pan; Christine T N Pham; Katherine N Weilbaecher; Michael H Tomasson; Samuel A Wickline; Gregory M Lanza
Journal:  Wiley Interdiscip Rev Nanomed Nanobiotechnol       Date:  2015-08-21

5.  Tumor-selective catalytic nanomedicine by nanocatalyst delivery.

Authors:  Minfeng Huo; Liying Wang; Yu Chen; Jianlin Shi
Journal:  Nat Commun       Date:  2017-08-25       Impact factor: 14.919

6.  Membrane reorganization after photochemical internalization to release transferrin-biofunctionalized polystyrene microparticles.

Authors:  Inmaculada Mora-Espí; Lleonard Barrios; Elena Ibáñez; Jorge Soriano; Carme Nogués
Journal:  Sci Rep       Date:  2018-12-04       Impact factor: 4.379

Review 7.  Integrating Stimuli-Responsive Properties in Host-Guest Supramolecular Drug Delivery Systems.

Authors:  Adam S Braegelman; Matthew J Webber
Journal:  Theranostics       Date:  2019-05-15       Impact factor: 11.556

Review 8.  Smart nanomedicine agents for cancer, triggered by pH, glutathione, H2O2, or H2S.

Authors:  Yaping Li; Lu An; Jiaomin Lin; Qiwei Tian; Shiping Yang
Journal:  Int J Nanomedicine       Date:  2019-07-24

9.  Redox-responsive magnetic nanoparticle for targeted convection-enhanced delivery of O6-benzylguanine to brain tumors.

Authors:  Zachary R Stephen; Forrest M Kievit; Omid Veiseh; Peter A Chiarelli; Chen Fang; Kui Wang; Shelby J Hatzinger; Richard G Ellenbogen; John R Silber; Miqin Zhang
Journal:  ACS Nano       Date:  2014-09-29       Impact factor: 15.881

Review 10.  Augmenting the Efficacy of Immunotoxins and Other Targeted Protein Toxins by Endosomal Escape Enhancers.

Authors:  Hendrik Fuchs; Alexander Weng; Roger Gilabert-Oriol
Journal:  Toxins (Basel)       Date:  2016-07-01       Impact factor: 4.546
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