BACKGROUND: Soluble intercellular adhesion molecule 1 (sICAM-1) is associated with endothelial dysfunction and clinical cardiovascular disease. We investigated the relationship of subclinical atherosclerosis with sICAM-1 concentration. METHODS: sICAM-1 concentration was assayed at year 15 of the Coronary Artery Risk Development in Young Adults (CARDIA) Study (black and white men and women, average age 40 years). We assessed progression of coronary artery calcification (CAC) through year 20 (n = 2378), and both carotid artery stenosis (n = 2432) and intima-media thickness (IMT) at year 20 (n = 2240). RESULTS: Median sICAM-1 was 145.9 μg/L. Among a subgroup with advanced atherosclerotic plaque (either CAC or stenosis), IMT was 0.010 (95% CI 0.003-0.017 mm) higher per SD of sICAM-1 (44 μg/L) in a model adjusted for age, race, sex, clinic, smoking, exercise, body size, education, blood pressure, antihypertensive medication, plasma lipids, and cholesterol-lowering medication. With the same adjustment, the odds ratio (OR) for the presence of year-20 carotid artery stenosis per SD of sICAM-1 was 1.12 (95% CI 1.01-1.25, P < 0.04), whereas for occurrence of CAC progression the OR was 1.16 (1.04-1.31, P < 0.01). The associations with CAC and carotid stenosis were strongest in the top 20th of the sICAM-1 distribution. CONCLUSIONS: sICAM-1 concentration may be an early biomarker that indicates changes in the artery wall that accompany atherosclerosis, as well as the presence of advanced plaque in the coronary and carotid arteries. This finding holds in people with low total burden of atherosclerosis, decades before the development of clinical CVD.
BACKGROUND: Soluble intercellular adhesion molecule 1 (sICAM-1) is associated with endothelial dysfunction and clinical cardiovascular disease. We investigated the relationship of subclinical atherosclerosis with sICAM-1 concentration. METHODS: sICAM-1 concentration was assayed at year 15 of the Coronary Artery Risk Development in Young Adults (CARDIA) Study (black and white men and women, average age 40 years). We assessed progression of coronary artery calcification (CAC) through year 20 (n = 2378), and both carotid artery stenosis (n = 2432) and intima-media thickness (IMT) at year 20 (n = 2240). RESULTS: Median sICAM-1 was 145.9 μg/L. Among a subgroup with advanced atherosclerotic plaque (either CAC or stenosis), IMT was 0.010 (95% CI 0.003-0.017 mm) higher per SD of sICAM-1 (44 μg/L) in a model adjusted for age, race, sex, clinic, smoking, exercise, body size, education, blood pressure, antihypertensive medication, plasma lipids, and cholesterol-lowering medication. With the same adjustment, the odds ratio (OR) for the presence of year-20 carotid artery stenosis per SD of sICAM-1 was 1.12 (95% CI 1.01-1.25, P < 0.04), whereas for occurrence of CAC progression the OR was 1.16 (1.04-1.31, P < 0.01). The associations with CAC and carotid stenosis were strongest in the top 20th of the sICAM-1 distribution. CONCLUSIONS: sICAM-1 concentration may be an early biomarker that indicates changes in the artery wall that accompany atherosclerosis, as well as the presence of advanced plaque in the coronary and carotid arteries. This finding holds in people with low total burden of atherosclerosis, decades before the development of clinical CVD.
Authors: Anand Rohatgi; Andrew W Owens; Amit Khera; Colby R Ayers; Kamakki Banks; Sandeep R Das; Jarett D Berry; Darren K McGuire; James A de Lemos Journal: Arterioscler Thromb Vasc Biol Date: 2009-10 Impact factor: 8.311
Authors: S Sidney; D R Jacobs; W L Haskell; M A Armstrong; A Dimicco; A Oberman; P J Savage; M L Slattery; B Sternfeld; L Van Horn Journal: Am J Epidemiol Date: 1991-06-15 Impact factor: 4.897
Authors: Maria Monagas; Nasiruddin Khan; Cristina Andres-Lacueva; Rosa Casas; Mireia Urpí-Sardà; Rafael Llorach; Rosa Maria Lamuela-Raventós; Ramón Estruch Journal: Am J Clin Nutr Date: 2009-09-23 Impact factor: 7.045
Authors: Mahdi Bijanzadeh; Nallur B Ramachandra; P A Mahesh; Mysore R Savitha; G S Vijayakumar; Pradeep Kumar; B S Manjunath; B S Jayaraj Journal: Lung Date: 2009-08-23 Impact factor: 2.584
Authors: Amy H Kao; Mary Chester M Wasko; Shanthi Krishnaswami; Joseph Wagner; Daniel Edmundowicz; Penny Shaw; Amy Lynn Cunningham; Natalya Danchenko; Kim Sutton-Tyrrell; Russell P Tracy; Lewis H Kuller; Susan Manzi Journal: Am J Cardiol Date: 2008-06-26 Impact factor: 2.778
Authors: Michelle A Albert; Guillaume Pare; Alanna Morris; Lynda Rose; Julie Buring; Paul M Ridker; Robert Y L Zee Journal: Am Heart J Date: 2009-04 Impact factor: 4.749
Authors: Andrew S Levey; Lesley A Stevens; Christopher H Schmid; Yaping Lucy Zhang; Alejandro F Castro; Harold I Feldman; John W Kusek; Paul Eggers; Frederick Van Lente; Tom Greene; Josef Coresh Journal: Ann Intern Med Date: 2009-05-05 Impact factor: 25.391
Authors: Weihong Tang; James S Pankow; J Jeffrey Carr; Russell P Tracy; Suzette J Bielinski; Kari E North; Paul N Hopkins; Aldi T Kraja; Donna K Arnett Journal: BMC Cardiovasc Disord Date: 2007-10-26 Impact factor: 2.298
Authors: Carla R Schubert; Mary E Fischer; A Alex Pinto; Yanjun Chen; Barbara E K Klein; Ronald Klein; Michael Y Tsai; Ted S Tweed; Karen J Cruickshanks Journal: J Am Geriatr Soc Date: 2019-04-01 Impact factor: 5.562
Authors: Jun Li; Dong Hoon Lee; Jie Hu; Fred K Tabung; Yanping Li; Shilpa N Bhupathiraju; Eric B Rimm; Kathryn M Rexrode; JoAnn E Manson; Walter C Willett; Edward L Giovannucci; Frank B Hu Journal: J Am Coll Cardiol Date: 2020-11-10 Impact factor: 24.094
Authors: Clara C Elbers; Yiran Guo; Vinicius Tragante; Erik P A van Iperen; Matthew B Lanktree; Berta Almoguera Castillo; Fang Chen; Lisa R Yanek; Mary K Wojczynski; Yun R Li; Bart Ferwerda; Christie M Ballantyne; Sarah G Buxbaum; Yii-Der Ida Chen; Wei-Min Chen; L Adrienne Cupples; Mary Cushman; Yanan Duan; David Duggan; Michele K Evans; Jyotika K Fernandes; Myriam Fornage; Melissa Garcia; W Timothy Garvey; Nicole Glazer; Felicia Gomez; Tamara B Harris; Indrani Halder; Virginia J Howard; Margaux F Keller; M Ilyas Kamboh; Charles Kooperberg; Stephen B Kritchevsky; Andrea LaCroix; Kiang Liu; Yongmei Liu; Kiran Musunuru; Anne B Newman; N Charlotte Onland-Moret; Jose Ordovas; Inga Peter; Wendy Post; Susan Redline; Steven E Reis; Richa Saxena; Pamela J Schreiner; Kelly A Volcik; Xingbin Wang; Salim Yusuf; Alan B Zonderland; Sonia S Anand; Diane M Becker; Bruce Psaty; Daniel J Rader; Alex P Reiner; Stephen S Rich; Jerome I Rotter; Michèle M Sale; Michael Y Tsai; Ingrid B Borecki; Robert A Hegele; Sekar Kathiresan; Michael A Nalls; Herman A Taylor; Hakon Hakonarson; Suthesh Sivapalaratnam; Folkert W Asselbergs; Fotios Drenos; James G Wilson; Brendan J Keating Journal: PLoS One Date: 2012-12-07 Impact factor: 3.240
Authors: Mark A Wallet; Thomas W Buford; Anna-Maria Joseph; Madhuri Sankuratri; Christiaan Leeuwenburgh; Marco Pahor; Todd Manini; John W Sleasman; Maureen M Goodenow Journal: BMC Immunol Date: 2015-07-24 Impact factor: 3.615
Authors: F P C Sijtsma; K A Meyer; L M Steffen; L Van Horn; J M Shikany; A O Odegaard; M D Gross; D Kromhout; D R Jacobs Journal: Nutr Metab Cardiovasc Dis Date: 2014-01-17 Impact factor: 4.666