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Literature DB >> 22179256

Role of (p)ppGpp in biofilm formation by Enterococcus faecalis.

Luis E Chávez de Paz¹, José A Lemos, Claes Wickström, Christine M Sedgley.

Abstract

Enterococcus faecalis strain OG1RF and its (p)ppGpp-deficient ΔrelA, ΔrelQ, and ΔrelA ΔrelQ mutants were grown in biofilms and evaluated for growth profiles, biofilm morphology, cell viability, and proteolytic activity. E. faecalis lacking (p)ppGpp had a diminished capacity to sustain biofilm formation over an extended period of time and expressed abundant proteolytic activity.

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Year: 2011 PMID： 22179256 PMCID： PMC3294496 DOI： 10.1128/AEM.07036-11

Source DB: PubMed Journal: Appl Environ Microbiol ISSN： 0099-2240 Impact factor: 4.792

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Review 10. Many birds with one stone: targeting the (p)ppGpp signaling pathway of bacteria to improve antimicrobial therapy.

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