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Literature DB >> 22178615

Nanomaterial-mediated CNS delivery of diagnostic and therapeutic agents.

Laura Biddlestone-Thorpe¹, Nicola Marchi, Kathy Guo, Chaitali Ghosh, Damir Janigro, Kristoffer Valerie, Hu Yang.

Abstract

Research into the diagnosis and treatment of central nervous system (CNS) diseases has been enhanced by rapid advances in nanotechnology and an expansion in the library of nanostructured carriers. This review discusses the latest applications of nanomaterials in the CNS with an emphasis on brain tumors. Novel administration routes and transport mechanisms for nanomaterial-mediated CNS delivery of diagnostic and therapeutic agents to bypass or cross the blood brain barrier (BBB) are also discussed. These include temporary disruption of the BBB, use of impregnated polymers (polymer wafers), convection-enhanced delivery (CED), and intranasal delivery. Moreover, an in vitro BBB model capable of mimicking geometrical, cellular and rheological features of the human cerebrovasculature has been developed. This is a useful tool that can be used for screening CNS nanoparticles or therapeutics prior to in vivo and clinical investigation. A discussion of this novel model is included.

Entities: Chemical Disease Gene Species

Mesh：

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Year: 2011 PMID： 22178615 PMCID： PMC3321130 DOI： 10.1016/j.addr.2011.11.014

Source DB: PubMed Journal: Adv Drug Deliv Rev ISSN： 0169-409X Impact factor: 15.470

79 in total

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Review 4. Targeting homologous recombination repair defects in cancer.

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Journal: Trends Pharmacol Sci Date: 2010-07-02 Impact factor: 14.819

5. Convection-enhanced delivery of macromolecules in the brain.

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Journal: Proc Natl Acad Sci U S A Date: 1994-03-15 Impact factor: 11.205

6. Transport of Poly(n-butylcyano-acrylate) nanoparticles across the blood-brain barrier in vitro and their influence on barrier integrity.

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Journal: Biochem Biophys Res Commun Date: 2011-02-03 Impact factor: 3.575

7. Cellular localization and functional significance of CYP3A4 in the human epileptic brain.

Authors: Chaitali Ghosh; Nicola Marchi; Nirav K Desai; Vikram Puvenna; Mohammed Hossain; Jorge Gonzalez-Martinez; Andreas V Alexopoulos; Damir Janigro
Journal: Epilepsia Date: 2011-02-05 Impact factor: 5.864

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9. Convection-enhanced delivery of nanoliposomal CPT-11 (irinotecan) and PEGylated liposomal doxorubicin (Doxil) in rodent intracranial brain tumor xenografts.

Authors: Michal T Krauze; Charles O Noble; Tomohiro Kawaguchi; Daryl Drummond; Dmitri B Kirpotin; Yoji Yamashita; Erika Kullberg; John Forsayeth; John W Park; Krystof S Bankiewicz
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10. Interstitial taxol delivered from a biodegradable polymer implant against experimental malignant glioma.

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18 in total

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3. Synthesis of water-soluble camptothecin-polyoxetane conjugates via click chemistry.

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4. Photothermal therapy of glioblastoma multiforme using multiwalled carbon nanotubes optimized for diffusion in extracellular space.

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Journal: ACS Biomater Sci Eng Date: 2016-05-09

5. ATM kinase inhibition preferentially sensitizes p53-mutant glioma to ionizing radiation.

Authors: Laura Biddlestone-Thorpe; Muhammad Sajjad; Elizabeth Rosenberg; Jason M Beckta; Nicholas C K Valerie; Mary Tokarz; Bret R Adams; Alison F Wagner; Ashraf Khalil; Donna Gilfor; Sarah E Golding; Sumitra Deb; David G Temesi; Alan Lau; Mark J O'Connor; Kevin S Choe; Luis F Parada; Sang Kyun Lim; Nitai D Mukhopadhyay; Kristoffer Valerie
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