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Literature DB >> 22178611

The methylthiolation reaction mediated by the Radical-SAM enzymes.

Mohamed Atta¹, Simon Arragain, Marc Fontecave, Etienne Mulliez, John F Hunt, Jon D Luff, Farhad Forouhar.

Abstract

Over the past 10 years, considerable progress has been made in our understanding of the mechanistic enzymology of the Radical-SAM enzymes. It is now clear that these enzymes appear to be involved in a remarkably wide range of chemically challenging reactions. This review article highlights mechanistic and structural aspects of the methylthiotransferases (MTTases) sub-class of the Radical-SAM enzymes. The mechanism of methylthio insertion, now observed to be performed by three different enzymes is an exciting unsolved problem. This article is part of a Special Issue entitled: Radical SAM enzymes and Radical Enzymology.

Entities: Chemical Disease Gene Species

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Year: 2011 PMID： 22178611 PMCID： PMC4150254 DOI： 10.1016/j.bbapap.2011.11.007

Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002

40 in total

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