| Literature DB >> 22178557 |
Naveen C Srivastav1, Neeraj Shakya, Sudha Bhavanam, Amogh Agrawal, Chris Tse, Nancy Desroches, Dennis Y Kunimoto, Rakesh Kumar.
Abstract
Several 5-alkyl (or halo)-3'-azido (amino or halo) analogs of pyrimidine nucleosides have been synthesized and evaluated against Mycobacterium bovis, Mycobacterium tuberculosis and Mycobacterium avium. Among these compounds, 3'-azido-5-ethyl-2',3'-dideoxyuridine (3) was found to have significant antimycobacterial activities against M. bovis (MIC(50)=1μg/mL), M. tuberculosis (MIC(50)=10μg/mL) and M. avium (MIC(50)=10μg/mL).Entities:
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Year: 2011 PMID： 22178557 DOI： 10.1016/j.bmcl.2011.11.114
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823