OBJECTIVE: To find the relationship between the polymorphism of the Tim-3 gene mononucleotide site rs10515746 (-574G > T), rs4704853 (-882C > T), rs13170556, rs6555849 and the allergic rhinitis (AR) susceptibility in a population of Uigurs and Hans from Xinjiang Uigur Autonomous Region of China. METHODS: The two mononucleotide polymorphism site of Uigur and Han AR patients and normal people were analyzed in Xinjiang in terms of SNaPshot SNP typing technique. The gene type and allelomorph frequency were than calculated. According to the Tim-3 gene layout, the gene type and the allelomorph frequency had been calculated. The Hardy-Weinberg balance law had been used for exam ination. RESULTS: There were no statistic differences between the genotype and alleles of each frequency [site rs10515746(-574G > T), rs4704853 (-882C > T), rs13170556 and rs6555849)] of Uighurs, in group AR and matched group (all P > 0.05). There were no statistic differences between the genotype and alleles of each frequency of Han people in group AR and matched group (all P > 0.05). Except Han cases site rs4704853, the distribution of other genotype and alleles of each frequency accord with heredity balance through the Hardy-Weinberg balance law. CONCLUSIONS: In Xinjiang Uigur autonomous region, locus of gene Tim-3, site rs10515746(-574G > T), rs4704853(-882C > T), rs13170556 and rs6555849, has the polymorphism of the Tim-3 gene mononucleotide. There is no correlation between AR susceptibility and Tim-3 gene mononucleotide site of Uigur people and Han people in Xinjiang.
OBJECTIVE: To find the relationship between the polymorphism of the Tim-3 gene mononucleotide site rs10515746 (-574G > T), rs4704853 (-882C > T), rs13170556, rs6555849 and the allergic rhinitis (AR) susceptibility in a population of Uigurs and Hans from Xinjiang Uigur Autonomous Region of China. METHODS: The two mononucleotide polymorphism site of Uigur and Han AR patients and normal people were analyzed in Xinjiang in terms of SNaPshot SNP typing technique. The gene type and allelomorph frequency were than calculated. According to the Tim-3 gene layout, the gene type and the allelomorph frequency had been calculated. The Hardy-Weinberg balance law had been used for exam ination. RESULTS: There were no statistic differences between the genotype and alleles of each frequency [site rs10515746(-574G > T), rs4704853 (-882C > T), rs13170556 and rs6555849)] of Uighurs, in group AR and matched group (all P > 0.05). There were no statistic differences between the genotype and alleles of each frequency of Han people in group AR and matched group (all P > 0.05). Except Han cases site rs4704853, the distribution of other genotype and alleles of each frequency accord with heredity balance through the Hardy-Weinberg balance law. CONCLUSIONS: In Xinjiang Uigur autonomous region, locus of gene Tim-3, site rs10515746(-574G > T), rs4704853(-882C > T), rs13170556 and rs6555849, has the polymorphism of the Tim-3 gene mononucleotide. There is no correlation between AR susceptibility and Tim-3 gene mononucleotide site of Uigur people and Han people in Xinjiang.