INTRODUCTION: Eosinophils in the circulating blood undergo apoptosis during sepsis syndromes induced by the action of certain cytokines. OBJECTIVE: The aim of the study was to evaluate the absolute eosinophils count (EC) as a marker of mortality in severe sepsis and septic shock. PATIENTS AND METHOD: A prospective cohort study of patients with a diagnosis of sepsis or septic shock admitted to the intensive care unit (ICU) of the Dr Gustavo Fricke Hospital between January 2008 and December 2009 was conducted. Daily EC in all patients was analyzed. Receiver operating characteristic curve analysis was used to assess the performance of the diagnostic test. RESULTS: We studied a total of 240 patients. The median age was 62 years (interquartile range [IQR], 48-72 years), and 67 (27.9%) died. The median EC in patients who died was 43 (IQR, 14-121), whereas in surviving patients, it was 168 (IQR, 98-292) (P < .001). When the EC on the fifth day of hospital stay was assessed, an area under the curve (AUC) of 0.64 (95% confidence interval, 0.55-0.73) was observed. Eosinophils count at intensive care unit discharge showed an area under the curve of 0.81 (95% confidence interval, 0.76-0.87). DISCUSSION: Eosinophils counts were lower in patients who died of sepsis than in those who survived, but its clinical usefulness seems limited. Their role as an indicator of clinical stability seems to be important.
INTRODUCTION: Eosinophils in the circulating blood undergo apoptosis during sepsis syndromes induced by the action of certain cytokines. OBJECTIVE: The aim of the study was to evaluate the absolute eosinophils count (EC) as a marker of mortality in severe sepsis and septic shock. PATIENTS AND METHOD: A prospective cohort study of patients with a diagnosis of sepsis or septic shock admitted to the intensive care unit (ICU) of the Dr Gustavo Fricke Hospital between January 2008 and December 2009 was conducted. Daily EC in all patients was analyzed. Receiver operating characteristic curve analysis was used to assess the performance of the diagnostic test. RESULTS: We studied a total of 240 patients. The median age was 62 years (interquartile range [IQR], 48-72 years), and 67 (27.9%) died. The median EC in patients who died was 43 (IQR, 14-121), whereas in surviving patients, it was 168 (IQR, 98-292) (P < .001). When the EC on the fifth day of hospital stay was assessed, an area under the curve (AUC) of 0.64 (95% confidence interval, 0.55-0.73) was observed. Eosinophils count at intensive care unit discharge showed an area under the curve of 0.81 (95% confidence interval, 0.76-0.87). DISCUSSION: Eosinophils counts were lower in patients who died of sepsis than in those who survived, but its clinical usefulness seems limited. Their role as an indicator of clinical stability seems to be important.
Authors: Yoon Hee Kim; Hyun Bin Park; Min Jung Kim; Hwan Soo Kim; Hee Seon Lee; Yoon Ki Han; Kyung Won Kim; Myung Hyun Sohn; Kyu-Earn Kim Journal: J Korean Med Sci Date: 2013-01-08 Impact factor: 2.153
Authors: Hacer Aktürk; Murat Sütçü; Selim Badur; Selda Hançerli Törün; Agop Çıtak; Oğuz Bülent Erol; Ayper Somer; Nuran Salman Journal: Turk Pediatri Ars Date: 2015-12-01
Authors: Ana Rodriguez-Fernandez; David Andaluz-Ojeda; Raquel Almansa; Mar Justel; Jose Maria Eiros; Raul Ortiz de Lejarazu Journal: Mediators Inflamm Date: 2013-09-03 Impact factor: 4.711
Authors: Zivan M Babic; Filip Z Zunic; Jelena M Pantic; Gordana D Radosavljevic; Ivan P Jovanovic; Nebojsa N Arsenijevic; Miodrag L Lukic Journal: J Biomed Sci Date: 2018-07-12 Impact factor: 8.410