OBJECTIVE: Due to the high signal intensity of cerebrospinal fluid (CSF), proton density-weighted (PD-w) images with long repeat times (TR) may be less able to detect periventricular lesions in patients with multiple sclerosis (MS). However, we have found good detectability of MS lesions with PD-w using long TR at 3 Tesla (3 T). For this reason, the aim of this study was to prospectively investigate the detectability of MS lesions at 3 T in PD-w compared with fluid-attenuated inversion recovery (FLAIR) sequences. PATIENTS AND METHODS: A total of 11 MS patients were examined by a 3T magnetic resonance (MR) scanner, and their MS lesions were prospectively analyzed on PD-w and FLAIR images by two evaluators; detectability was rated by a three-point scoring system. The Wilcoxon signed-rank test was used for comparisons, and the level of significance was P<0.05. RESULTS: Significantly more lesions were detectable on PD-w images (P<0.001 for both evaluators). In particular, PD-w was superior to FLAIR for the detection of periventricular (P=0.001 and P=0.013 for each evaluator respectively) and infratentorial (P<0.001 for both evaluators) lesions. CONCLUSION: This was the first study to compare FLAIR and PD-w with long TR at 3 T; it revealed that PD-w is superior for detecting infratentorial and even periventricular MS lesions, despite the higher signal intensity of CSF. This might be due to the high spin density of MS lesions, thus distinguishing them from the surrounding brain tissue. For this reason, double-echo T2-weighted sequences at 3T are recommended to improve the detectability of MS lesions.
OBJECTIVE: Due to the high signal intensity of cerebrospinal fluid (CSF), proton density-weighted (PD-w) images with long repeat times (TR) may be less able to detect periventricular lesions in patients with multiple sclerosis (MS). However, we have found good detectability of MS lesions with PD-w using long TR at 3 Tesla (3 T). For this reason, the aim of this study was to prospectively investigate the detectability of MS lesions at 3 T in PD-w compared with fluid-attenuated inversion recovery (FLAIR) sequences. PATIENTS AND METHODS: A total of 11 MS patients were examined by a 3T magnetic resonance (MR) scanner, and their MS lesions were prospectively analyzed on PD-w and FLAIR images by two evaluators; detectability was rated by a three-point scoring system. The Wilcoxon signed-rank test was used for comparisons, and the level of significance was P<0.05. RESULTS: Significantly more lesions were detectable on PD-w images (P<0.001 for both evaluators). In particular, PD-w was superior to FLAIR for the detection of periventricular (P=0.001 and P=0.013 for each evaluator respectively) and infratentorial (P<0.001 for both evaluators) lesions. CONCLUSION: This was the first study to compare FLAIR and PD-w with long TR at 3 T; it revealed that PD-w is superior for detecting infratentorial and even periventricular MS lesions, despite the higher signal intensity of CSF. This might be due to the high spin density of MS lesions, thus distinguishing them from the surrounding brain tissue. For this reason, double-echo T2-weighted sequences at 3T are recommended to improve the detectability of MS lesions.
Authors: Eike Steidl; Maximilian Rauch; Elke Hattingen; Stella Breuer; Jan Rüdiger Schüre; Marike Grapengeter; Manoj Shrestha; Christian Foerch; Martin A Schaller-Paule Journal: Front Neurol Date: 2022-08-03 Impact factor: 4.086
Authors: Martin A Schaller-Paule; Eike Steidl; Manoj Shrestha; Ralf Deichmann; Helmuth Steinmetz; Alexander Seiler; Sriramya Lapa; Thorsten Steiner; Sven Thonke; Stefan Weidauer; Juergen Konczalla; Elke Hattingen; Christian Foerch Journal: Front Neurol Date: 2021-07-16 Impact factor: 4.003