AIMS: Lennert's lymphoma is a rare variant of peripheral T-cell lymphoma (PTCL) not otherwise specified (NOS). The aim of this study was to further characterize this tumour. METHODS AND RESULTS: Historical material of 97 lymphomas with a high content of epithelioid cells, collected at the Kiel Lymph Node Registry were reviewed, by applying immunohistochemistry and current diagnostic criteria. Among all cases revised, various B-cell lymphoma entities (25 cases), Hodgkin lymphomas (21 cases) and PTCL subtypes (48 cases) could be identified. A distinctive subgroup of eight PTCLs was found that were regarded as genuine Lennert's lymphomas. These cases were characterized by mild atypia, a non-activated cytotoxic phenotype [TIA1 cytotoxic granule-associated RNA binding protein (TIA1)-positive(+) and granzyme B-negative], and a substantial lack of follicular T-helper (T(FH) ) cell markers. Among the other PTCLs, including angioimmunoblastic T-cell lymphoma and PTCL NOS, many cases with positivity for more than three T(FH) cell-associated molecules were recorded. CONCLUSIONS: Our study shows that, according to current criteria, Lennert's lymphoma is a rare but distinctive entity among epithelioid cell-rich lymphomas, differing on grounds of morphology and immunophenotype from other PTCL subtypes. An additional finding is the broad morphological spectrum of epithelioid-cell rich PTCLs showing a T(FH) cell phenotype.
AIMS: Lennert's lymphoma is a rare variant of peripheral T-cell lymphoma (PTCL) not otherwise specified (NOS). The aim of this study was to further characterize this tumour. METHODS AND RESULTS: Historical material of 97 lymphomas with a high content of epithelioid cells, collected at the Kiel Lymph Node Registry were reviewed, by applying immunohistochemistry and current diagnostic criteria. Among all cases revised, various B-cell lymphoma entities (25 cases), Hodgkin lymphomas (21 cases) and PTCL subtypes (48 cases) could be identified. A distinctive subgroup of eight PTCLs was found that were regarded as genuine Lennert's lymphomas. These cases were characterized by mild atypia, a non-activated cytotoxic phenotype [TIA1 cytotoxic granule-associated RNA binding protein (TIA1)-positive(+) and granzyme B-negative], and a substantial lack of follicular T-helper (T(FH) ) cell markers. Among the other PTCLs, including angioimmunoblastic T-cell lymphoma and PTCL NOS, many cases with positivity for more than three T(FH) cell-associated molecules were recorded. CONCLUSIONS: Our study shows that, according to current criteria, Lennert's lymphoma is a rare but distinctive entity among epithelioid cell-rich lymphomas, differing on grounds of morphology and immunophenotype from other PTCL subtypes. An additional finding is the broad morphological spectrum of epithelioid-cell rich PTCLs showing a T(FH) cell phenotype.
Authors: Benjamin Rengstl; Frederike Schmid; Christian Weiser; Claudia Döring; Tim Heinrich; Kathrin Warner; Petra S A Becker; Robin Wistinghausen; Sima Kameh-Var; Eva Werling; Arne Billmeier; Christian Seidl; Sylvia Hartmann; Hinrich Abken; Ralf Küppers; Martin-Leo Hansmann; Sebastian Newrzela Journal: Oncoimmunology Date: 2016-03-16 Impact factor: 8.110
Authors: Philip Eichhorn; Udo Andraschke; Fritz Dross; Carol I Geppert; Arndt Hartmann; Tilman T Rau Journal: Virchows Arch Date: 2018-05-10 Impact factor: 4.064
Authors: K D Wurster; F Hummel; J Richter; M Giefing; S Hartmann; M-L Hansmann; S Kreher; K Köchert; D Krappmann; W Klapper; M Hummel; S-S Wenzel; G Lenz; M Janz; B Dörken; R Siebert; S Mathas Journal: Leukemia Date: 2016-08-19 Impact factor: 11.528
Authors: Sylvia Hartmann; Claudia Döring; Christina Jakobus; Benjamin Rengstl; Sebastian Newrzela; Thomas Tousseyn; Xavier Sagaert; Maurilio Ponzoni; Fabio Facchetti; Chris de Wolf-Peeters; Christian Steidl; Randy Gascoyne; Ralf Küppers; Martin-Leo Hansmann Journal: PLoS One Date: 2013-11-11 Impact factor: 3.240