David M Burch1, Fattaneh A Tavassoli. 1. Department of Gynecologic and Breast Pathology, The Armed Forces Institute of Pathology, Washington, DC, USA.
Abstract
AIMS: Recent guidelines have suggested the presence of tumour cell necrosis (TCN), atypia and mitotic index as major features in the distinction of myxoid leiomyosarcomas (MLMSs) from myxoid leiomyomas. The aim of this study was to focus on an invasive growth pattern as a significant feature in this distinction in the absence of TCN. METHODS AND RESULTS: Twelve uterine smooth muscle tumours with myxoid change in ≥60% of the lesion were interpreted as MLMS on the basis of the presence of focal mild atypia as well as one or more of the following features: (i) infiltrative growth pattern; (ii) vascular invasion; (iii) mitotic index of ≥5 mitotic figures (m.f.)/50 high-power fields (HPFs); and (iv) a combination of at least focal severe atypia and at least 2-4 m.f./50 HPFs. Unequivocal TCN was not evident in any of these tumours. The various morphological features were correlated with outcome. With follow-ups ranging from 19 to 113 months (mean 60 months), five of the 12 women developed recurrences, and two of them died. Nine of the 12 tumours had an infiltrative growth pattern, and all five recurrent tumours were from this group. CONCLUSION: In the absence of TCN, an infiltrative margin is a major factor related to the potential for aggressive behaviour of MLMS.
AIMS: Recent guidelines have suggested the presence of tumour cell necrosis (TCN), atypia and mitotic index as major features in the distinction of myxoid leiomyosarcomas (MLMSs) from myxoid leiomyomas. The aim of this study was to focus on an invasive growth pattern as a significant feature in this distinction in the absence of TCN. METHODS AND RESULTS: Twelve uterine smooth muscle tumours with myxoid change in ≥60% of the lesion were interpreted as MLMS on the basis of the presence of focal mild atypia as well as one or more of the following features: (i) infiltrative growth pattern; (ii) vascular invasion; (iii) mitotic index of ≥5 mitotic figures (m.f.)/50 high-power fields (HPFs); and (iv) a combination of at least focal severe atypia and at least 2-4 m.f./50 HPFs. Unequivocal TCN was not evident in any of these tumours. The various morphological features were correlated with outcome. With follow-ups ranging from 19 to 113 months (mean 60 months), five of the 12 women developed recurrences, and two of them died. Nine of the 12 tumours had an infiltrative growth pattern, and all five recurrent tumours were from this group. CONCLUSION: In the absence of TCN, an infiltrative margin is a major factor related to the potential for aggressive behaviour of MLMS.
Authors: Javier A Arias-Stella; Ryma Benayed; Esther Oliva; Robert H Young; Lien N Hoang; Cheng-Han Lee; Achim A Jungbluth; Denise Frosina; Robert A Soslow; Cristina R Antonescu; Marc Ladanyi; Sarah Chiang Journal: Am J Surg Pathol Date: 2019-03 Impact factor: 6.298
Authors: Alberto Bongiovanni; Nada Riva; Marianna Ricci; Laura Mercatali; Chiara Liverani; Federico La Manna; Alessandro De Vita; Davide Cavaliere; Federica Pieri; Devil Oboldi; Giorgio Maria Verdecchia; Dino Amadori; Toni Ibrahim Journal: BMC Cancer Date: 2015-12-22 Impact factor: 4.430