BACKGROUND: Cortical spreading depression (CSD) has an important role in migraine with aura. Prolonged neuronal depression is followed by a late excitatory synaptic plasticity after CSD. METHOD: Intra- and extracellular recordings were performed to investigate the effect of CSD on intracellular properties of mouse neocortical tissues in the late excitatory period. RESULTS: During CSD, changes in the membrane potentials usually began with a relatively short hyperpolarization followed by an abrupt depolarization. These changes occurred roughly at the same time point after CSD as the beginning of the negative extracellular deflection. Forty-five minutes after CSD, neurons showed significantly smaller amplitude of afterhyperpolarization and a reduced input resistance. Depolarization and hyperpolarization of the cells by constant intracellular current injections in this period significantly changed the frequency of the action potentials. CONCLUSION: These data indicate higher excitability of the neocortical neurons after CSD, which can be assumed to contribute to hyperexcitability of neocortical tissues in patients suffering from migraine.
BACKGROUND: Cortical spreading depression (CSD) has an important role in migraine with aura. Prolonged neuronal depression is followed by a late excitatory synaptic plasticity after CSD. METHOD: Intra- and extracellular recordings were performed to investigate the effect of CSD on intracellular properties of mouse neocortical tissues in the late excitatory period. RESULTS: During CSD, changes in the membrane potentials usually began with a relatively short hyperpolarization followed by an abrupt depolarization. These changes occurred roughly at the same time point after CSD as the beginning of the negative extracellular deflection. Forty-five minutes after CSD, neurons showed significantly smaller amplitude of afterhyperpolarization and a reduced input resistance. Depolarization and hyperpolarization of the cells by constant intracellular current injections in this period significantly changed the frequency of the action potentials. CONCLUSION: These data indicate higher excitability of the neocortical neurons after CSD, which can be assumed to contribute to hyperexcitability of neocortical tissues in patients suffering from migraine.
Authors: Katharina Eikermann-Haerter; Jeong Hyun Lee; Nilufer Yalcin; Esther S Yu; Ali Daneshmand; Ying Wei; Yi Zheng; Anil Can; Buse Sengul; Michel D Ferrari; Arn M J M van den Maagdenberg; Cenk Ayata Journal: Stroke Date: 2014-11-25 Impact factor: 7.914
Authors: R David Andrew; Jed A Hartings; Cenk Ayata; K C Brennan; Ken D Dawson-Scully; Eszter Farkas; Oscar Herreras; Sergei A Kirov; Michael Müller; Nikita Ollen-Bittle; Clemens Reiffurth; Omer Revah; R Meldrum Robertson; C William Shuttleworth; Ghanim Ullah; Jens P Dreier Journal: Neurocrit Care Date: 2022-03-07 Impact factor: 3.532
Authors: Olga Cozzolino; Maria Marchese; Francesco Trovato; Enrico Pracucci; Gian Michele Ratto; Maria Gabriella Buzzi; Federico Sicca; Filippo M Santorelli Journal: Front Neurol Date: 2018-02-01 Impact factor: 4.003