OBJECTIVE: To determine the impact of cerebellar hemorrhage (CH) on mortality and adverse neurodevelopmental (ND) outcome rates in extremely preterm infants admitted to a tertiary neonatal unit. STUDY DESIGN: A total of 1120 eligible infants (<28 weeks gestation) were born from 1998 to 2008 and had at least one cranial ultrasound. ND outcome was determined at 12 to 18 months corrected age. RESULTS: Most CH (75%) occurred in infants <25 weeks gestation. CH did not affect mortality rates, however, it was associated with both mental and motor impairments, with incidence rate ratios of 3.08 (1.71 to 4.84) and 2.12 (1.12 to 3.45), respectively. Moreover, the risk of cerebral palsy (CP) was increased in infants with CH involving the medial part of the cerebellum. CONCLUSION: Our findings substantiate recent reports about the cerebellum, highlighting its role in cognitive and executive functions, and associating early cerebellar injury not only with CP but also with learning, affective and behavioral disorders.
OBJECTIVE: To determine the impact of cerebellar hemorrhage (CH) on mortality and adverse neurodevelopmental (ND) outcome rates in extremely preterm infants admitted to a tertiary neonatal unit. STUDY DESIGN: A total of 1120 eligible infants (<28 weeks gestation) were born from 1998 to 2008 and had at least one cranial ultrasound. ND outcome was determined at 12 to 18 months corrected age. RESULTS: Most CH (75%) occurred in infants <25 weeks gestation. CH did not affect mortality rates, however, it was associated with both mental and motor impairments, with incidence rate ratios of 3.08 (1.71 to 4.84) and 2.12 (1.12 to 3.45), respectively. Moreover, the risk of cerebral palsy (CP) was increased in infants with CH involving the medial part of the cerebellum. CONCLUSION: Our findings substantiate recent reports about the cerebellum, highlighting its role in cognitive and executive functions, and associating early cerebellar injury not only with CP but also with learning, affective and behavioral disorders.
Authors: Sylke J Steggerda; Francisca T De Bruïne; Annette A van den Berg-Huysmans; Monique Rijken; Lara M Leijser; Frans J Walther; Gerda van Wezel-Meijler Journal: Cerebellum Date: 2013-12 Impact factor: 3.847
Authors: Karl C K Kuban; Hernan Jara; T Michael O'Shea; Timothy Heeren; Robert M Joseph; Raina N Fichorova; Khalid Alshamrani; Adam Aakil; Forrest Beaulieu; Mitchell Horn; Laurie M Douglass; Jean A Frazier; Deborah Hirtz; Julie Vanier Rollins; David Cochran; Nigel Paneth Journal: J Pediatr Date: 2019-05-07 Impact factor: 4.406
Authors: V Boswinkel; S J Steggerda; M Fumagalli; A Parodi; L A Ramenghi; F Groenendaal; J Dudink; M N Benders; R Knol; L S de Vries; G van Wezel-Meijler Journal: Cerebellum Date: 2019-12 Impact factor: 3.847
Authors: Dawn Gano; Mai-Lan Ho; John Colin Partridge; Hannah C Glass; Duan Xu; A James Barkovich; Donna M Ferriero Journal: J Pediatr Date: 2016-07-22 Impact factor: 4.406
Authors: Giulia Spoto; Greta Amore; Luigi Vetri; Giuseppe Quatrosi; Anna Cafeo; Eloisa Gitto; Antonio Gennaro Nicotera; Gabriella Di Rosa Journal: Front Syst Neurosci Date: 2021-06-10