Literature DB >> 22172719

Targeting liver cancer: first steps toward a miRacle?

Robert F Schwabe1, Timothy C Wang.   

Abstract

In a recent issue of Cell, Iliopoulos and colleagues demonstrate a novel and targetable epigenetic amplification loop in hepatocellular carcinoma involving HNF4α, miR-124, IL6-R, Stat3, miR-24, and miR-629. These results establish microRNAs as novel players in early stages of hepatocarcinogenesis and as potential targets for the treatment of hepatocellular carcinoma.
Copyright © 2011 Elsevier Inc. All rights reserved.

Entities:  

Year:  2011        PMID： 22172719      PMCID： PMC3619204          DOI： 10.1016/j.ccr.2011.11.021

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  10 in total

Review 1.  Hepatocellular carcinoma.

Authors:  Hashem B El-Serag
Journal:  N Engl J Med       Date:  2011-09-22       Impact factor: 91.245

2.  Gain of miR-151 on chromosome 8q24.3 facilitates tumour cell migration and spreading through downregulating RhoGDIA.

Authors:  Jie Ding; Shenglin Huang; Shunquan Wu; Yingjun Zhao; Linhui Liang; Mingxia Yan; Chao Ge; Jian Yao; Taoyang Chen; Dafang Wan; Hongyang Wang; Jianren Gu; Ming Yao; Jinjun Li; Hong Tu; Xianghuo He
Journal:  Nat Cell Biol       Date:  2010-03-21       Impact factor: 28.824

3.  An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation.

Authors:  Dimitrios Iliopoulos; Heather A Hirsch; Kevin Struhl
Journal:  Cell       Date:  2009-10-29       Impact factor: 41.582

4.  Identification of miRNomes in human liver and hepatocellular carcinoma reveals miR-199a/b-3p as therapeutic target for hepatocellular carcinoma.

Authors:  Jin Hou; Li Lin; Weiping Zhou; Zhengxin Wang; Guoshan Ding; Qiongzhu Dong; Lunxiu Qin; Xiaobing Wu; Yuanyuan Zheng; Yun Yang; Wei Tian; Qian Zhang; Chunmei Wang; Qinghua Zhang; Shi-Mei Zhuang; Limin Zheng; Anmin Liang; Wenzhao Tao; Xuetao Cao
Journal:  Cancer Cell       Date:  2011-02-15       Impact factor: 31.743

5.  An HNF4α-miRNA inflammatory feedback circuit regulates hepatocellular oncogenesis.

Authors:  Maria Hatziapostolou; Christos Polytarchou; Eleni Aggelidou; Alexandra Drakaki; George A Poultsides; Savina A Jaeger; Hisanobu Ogata; Michael Karin; Kevin Struhl; Margarita Hadzopoulou-Cladaras; Dimitrios Iliopoulos
Journal:  Cell       Date:  2011-12-09       Impact factor: 41.582

6.  MicroRNA expression, survival, and response to interferon in liver cancer.

Authors:  Junfang Ji; Jiong Shi; Anuradha Budhu; Zhipeng Yu; Marshonna Forgues; Stephanie Roessler; Stefan Ambs; Yidong Chen; Paul S Meltzer; Carlo M Croce; Lun-Xiu Qin; Kwan Man; Chung-Mau Lo; Joyce Lee; Irene O L Ng; Jia Fan; Zhao-You Tang; Hui-Chuan Sun; Xin Wei Wang
Journal:  N Engl J Med       Date:  2009-10-08       Impact factor: 91.245

7.  Gene expression in fixed tissues and outcome in hepatocellular carcinoma.

Authors:  Yujin Hoshida; Augusto Villanueva; Masahiro Kobayashi; Judit Peix; Derek Y Chiang; Amy Camargo; Supriya Gupta; Jamie Moore; Matthew J Wrobel; Jim Lerner; Michael Reich; Jennifer A Chan; Jonathan N Glickman; Kenji Ikeda; Masaji Hashimoto; Goro Watanabe; Maria G Daidone; Sasan Roayaie; Myron Schwartz; Swan Thung; Helga B Salvesen; Stacey Gabriel; Vincenzo Mazzaferro; Jordi Bruix; Scott L Friedman; Hiromitsu Kumada; Josep M Llovet; Todd R Golub
Journal:  N Engl J Med       Date:  2008-10-15       Impact factor: 91.245

8.  Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production.

Authors:  Willscott E Naugler; Toshiharu Sakurai; Sunhwa Kim; Shin Maeda; Kyounghyun Kim; Ahmed M Elsharkawy; Michael Karin
Journal:  Science       Date:  2007-07-06       Impact factor: 47.728

9.  Sorafenib in advanced hepatocellular carcinoma.

Authors:  Josep M Llovet; Sergio Ricci; Vincenzo Mazzaferro; Philip Hilgard; Edward Gane; Jean-Frédéric Blanc; Andre Cosme de Oliveira; Armando Santoro; Jean-Luc Raoul; Alejandro Forner; Myron Schwartz; Camillo Porta; Stefan Zeuzem; Luigi Bolondi; Tim F Greten; Peter R Galle; Jean-François Seitz; Ivan Borbath; Dieter Häussinger; Tom Giannaris; Minghua Shan; Marius Moscovici; Dimitris Voliotis; Jordi Bruix
Journal:  N Engl J Med       Date:  2008-07-24       Impact factor: 91.245

10.  Hepatocyte nuclear factor 4alpha controls the development of a hepatic epithelium and liver morphogenesis.

Authors:  Fereshteh Parviz; Christine Matullo; Wendy D Garrison; Laura Savatski; John W Adamson; Gang Ning; Klaus H Kaestner; Jennifer M Rossi; Kenneth S Zaret; Stephen A Duncan
Journal:  Nat Genet       Date:  2003-07       Impact factor: 38.330
  10 in total
  21 in total

1.  Serum microRNAs; miR-30c-5p, miR-223-3p, miR-302c-3p and miR-17-5p could be used as novel non-invasive biomarkers for HCV-positive cirrhosis and hepatocellular carcinoma.

Authors:  Zehra Oksuz; Mehmet Sami Serin; Engin Kaplan; Aylin Dogen; Seda Tezcan; Gonul Aslan; Gurol Emekdas; Orhan Sezgin; Engin Altintas; Eyup Naci Tiftik
Journal:  Mol Biol Rep       Date:  2014-11-13       Impact factor: 2.316

Review 2.  STAT3 in hepatocellular carcinoma: new perspectives.

Authors:  Jasmin Svinka; Wolfgang Mikulits; Robert Eferl
Journal:  Hepat Oncol       Date:  2013-12-20

3.  U/G SNP rs111904020 in 3'UTR of STAT3 regulated by miR-214 promotes hepatocellular carcinoma development in Chinese population.

Authors:  Ye Fan; Xiaofeng Qian; Chuanyong Zhang
Journal:  Tumour Biol       Date:  2016-09-12

4.  miR-124 functions as a tumor suppressor in the endometrial carcinoma cell line HEC-1B partly by suppressing STAT3.

Authors:  Yunyun Li; Zhongzu Zhang; Xiuxia Liu; Tingting Huang; Wenfeng He; Yang Shen; Xin Liu; Kui Hong; Qing Cao
Journal:  Mol Cell Biochem       Date:  2013-11-28       Impact factor: 3.396

5.  miR-124 and Androgen Receptor Signaling Inhibitors Repress Prostate Cancer Growth by Downregulating Androgen Receptor Splice Variants, EZH2, and Src.

Authors:  Xu-Bao Shi; Ai-Hong Ma; Lingru Xue; Meimei Li; Hao G Nguyen; Joy C Yang; Clifford G Tepper; Regina Gandour-Edwards; Christopher P Evans; Hsing-Jien Kung; Ralph W deVere White
Journal:  Cancer Res       Date:  2015-11-16       Impact factor: 12.701

6.  Age-associated change of C/EBP family proteins causes severe liver injury and acceleration of liver proliferation after CCl4 treatments.

Authors:  Il-Hwa Hong; Kyle Lewis; Polina Iakova; Jingling Jin; Emily Sullivan; Nicole Jawanmardi; Lubov Timchenko; Nikolai Timchenko
Journal:  J Biol Chem       Date:  2013-11-22       Impact factor: 5.157

7.  Let-7a functions as a tumor suppressor in Ewing's sarcoma cell lines partly by targeting cyclin-dependent kinase 6.

Authors:  Zhongzu Zhang; Lu Huang; Zhiming Yu; Xiang Chen; Dong Yang; Ping Zhan; Min Dai; Shanhu Huang; Zhimin Han; Kai Cao
Journal:  DNA Cell Biol       Date:  2014-01-02       Impact factor: 3.311

8.  MicroRNA-424 is down-regulated in hepatocellular carcinoma and suppresses cell migration and invasion through c-Myb.

Authors:  Lei Yu; Guo-feng Ding; Changzhi He; Lei Sun; YanFang Jiang; Liying Zhu
Journal:  PLoS One       Date:  2014-03-27       Impact factor: 3.752

9.  Viral non-coding RNA inhibits HNF4α expression in HCV associated hepatocellular carcinoma.

Authors:  Zhao Wang; Kristin Ceniccola; Liliana Florea; Bi-Dar Wang; Norman H Lee; Ajit Kumar
Journal:  Infect Agent Cancer       Date:  2015-07-08       Impact factor: 2.965

10.  Establishing reliable miRNA-cancer association network based on text-mining method.

Authors:  Lun Li; Xingchi Hu; Zhaowan Yang; Zhenyu Jia; Ming Fang; Libin Zhang; Yanhong Zhou
Journal:  Comput Math Methods Med       Date:  2014-04-10       Impact factor: 2.238
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