Literature DB >> 22172717

"Ring-fencing" BRCA1 tumor suppressor activity.

Ketan J Patel1, Gerry P Crossan, Michael R G Hodskinson.   

Abstract

BRCA1 is a crucial human breast and ovarian cancer tumor suppressor gene. The article by Drost et al. in this issue of Cancer Cell together with a recent paper in Science now provide a clearer picture of how this large and complex protein suppresses tumorigenesis.
Copyright © 2011 Elsevier Inc. All rights reserved.

Entities:  

Year:  2011        PMID： 22172717     DOI： 10.1016/j.ccr.2011.11.019

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  2 in total

1.  BRCA1185delAG tumors may acquire therapy resistance through expression of RING-less BRCA1.

Authors:  Rinske Drost; Kiranjit K Dhillon; Hanneke van der Gulden; Ingrid van der Heijden; Inger Brandsma; Cristina Cruz; Dafni Chondronasiou; Marta Castroviejo-Bermejo; Ute Boon; Eva Schut; Eline van der Burg; Ellen Wientjens; Mark Pieterse; Christiaan Klijn; Sjoerd Klarenbeek; Fabricio Loayza-Puch; Ran Elkon; Liesbeth van Deemter; Sven Rottenberg; Marieke van de Ven; Dick H W Dekkers; Jeroen A A Demmers; Dik C van Gent; Reuven Agami; Judith Balmaña; Violeta Serra; Toshiyasu Taniguchi; Peter Bouwman; Jos Jonkers
Journal:  J Clin Invest       Date:  2016-07-25       Impact factor: 14.808

2.  Allele-specific expression mediates primary resistance to poly (ADP-ribose) polymerase inhibitor therapy in a case of BRCA1/2 double-germline mutant gastric cancer.

Authors:  Lu Wen; Xiuxiu Li; Junping Shi; Shuo Zhang; Rui Wang; Ming Yao; Jun Guo
Journal:  J Int Med Res       Date:  2019-11-27       Impact factor: 1.671
  2 in total

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