| Literature DB >> 22172716 |
Michele W L Teng1, Phillip K Darcy, Mark J Smyth.
Abstract
In this issue of Cancer Cell, Mumm et al. demonstrate that pegylated IL-10 increases CD8(+) T cell numbers, IFN-γ secretion, and cytotoxicity in established tumors, enhancing antigen presentation machinery and suppressing tumor growth. This approach may enhance T cell immune responses in cancers with reduced T cell infiltration.Entities:
Year: 2011 PMID： 22172716 DOI： 10.1016/j.ccr.2011.11.020
Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743