Literature DB >> 22172627

Histidine kinases and response regulators in networks.

Kirsten Jung1, Luitpold Fried, Stefan Behr, Ralf Heermann.   

Abstract

Two-component systems, composed of a histidine kinase (HK) and a response regulator (RR), are the major signal transduction devices in bacteria. Originally it was thought that these two components function as linear, phosphorylation-driven stimulus-response system. Here, we will review how accessory proteins are employed by HKs and RRs to mediate signal integration, scaffolding, interconnection and allosteric regulation, and how these two components are embedded in regulatory networks.
Copyright © 2011 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID： 22172627     DOI： 10.1016/j.mib.2011.11.009

Source DB:  PubMed          Journal:  Curr Opin Microbiol        ISSN： 1369-5274            Impact factor:   7.934


  91 in total

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