PURPOSE: To investigate the effect of fat infiltration on the apparent diffusion coefficient (ADC) of liver, and assess the relationship between ADC and hepatic fat fraction (HFF). MATERIALS AND METHODS: MRI scans of 120 consecutive patients were included in this retrospective study. Of these, 42 patients were included in the fatty liver group and 78 in the control group. ADC values were measured from a pair of diffusion-weighted (DW) images (b = 0 mm(2) /s and 1000 mm(2) /s). HFFs were measured using T1W GRE dual-echo images. The difference between the ADCs of the two groups was assessed with the t-test. The relationship between HFF and ADC was determined using linear regression analysis and the Pearson correlation coefficient (r). RESULTS: Mean HFFs were 0.85 ± 2.86 and 13.67 ± 8.62 in the control and fatty liver groups, respectively. The mean ADC of fatty liver group 1.20 ± 0.22 × 10(-3) mm(2) /s was significantly lower than that of the control group 1.32 ± 0.23 × 10(-3) mm(2) /s (P = 0.02). Linear regression analysis revealed an inverse relationship between ADC and HFF (r = -0.39, P < 0.0001). CONCLUSION: ADC significantly decreases in patients with >5% HFF, and ADC and HFF exhibit an inverse relationship.
PURPOSE: To investigate the effect of fat infiltration on the apparent diffusion coefficient (ADC) of liver, and assess the relationship between ADC and hepatic fat fraction (HFF). MATERIALS AND METHODS: MRI scans of 120 consecutive patients were included in this retrospective study. Of these, 42 patients were included in the fatty liver group and 78 in the control group. ADC values were measured from a pair of diffusion-weighted (DW) images (b = 0 mm(2) /s and 1000 mm(2) /s). HFFs were measured using T1W GRE dual-echo images. The difference between the ADCs of the two groups was assessed with the t-test. The relationship between HFF and ADC was determined using linear regression analysis and the Pearson correlation coefficient (r). RESULTS: Mean HFFs were 0.85 ± 2.86 and 13.67 ± 8.62 in the control and fatty liver groups, respectively. The mean ADC of fatty liver group 1.20 ± 0.22 × 10(-3) mm(2) /s was significantly lower than that of the control group 1.32 ± 0.23 × 10(-3) mm(2) /s (P = 0.02). Linear regression analysis revealed an inverse relationship between ADC and HFF (r = -0.39, P < 0.0001). CONCLUSION: ADC significantly decreases in patients with >5% HFF, and ADC and HFF exhibit an inverse relationship.
Authors: Paul Murphy; Jonathan Hooker; Brandon Ang; Tanya Wolfson; Anthony Gamst; Mark Bydder; Michael Middleton; Michael Peterson; Cynthia Behling; Rohit Loomba; Claude Sirlin Journal: J Magn Reson Imaging Date: 2014-09-25 Impact factor: 4.813
Authors: Helena S Leitão; Sabrina Doblas; Gaspard d'Assignies; Philippe Garteiser; Jean-Luc Daire; Valérie Paradis; Carlos F G C Geraldes; Valérie Vilgrain; Bernard E Van Beers Journal: Eur Radiol Date: 2012-09-01 Impact factor: 5.315
Authors: Paul Manning; Paul Murphy; Kang Wang; Jonathan Hooker; Tanya Wolfson; Michael S Middleton; Kimberly P Newton; Cynthia Behling; Hannah I Awai; Janis Durelle; Melissa N Paiz; Jorge E Angeles; Diana De La Pena; J Allen McCutchan; Jeffrey B Schwimmer; Claude B Sirlin Journal: J Magn Reson Imaging Date: 2017-02-22 Impact factor: 4.813