Literature DB >> 22170597

Polymorphism of the prion protein gene (PRNP) in Polish cattle affected by classical bovine spongiform encephalopathy.

Artur Gurgul1, Urszula Czarnik, Czarnik Urszula, Magdalena Larska, Mirosław P Polak, Janusz Strychalski, Ewa Słota.   

Abstract

Recent attempts to discover genetic factors affecting cattle resistance/susceptibility to bovine spongiform encephalopathy (BSE) have led to the identification of two insertion/deletion (indel) polymorphisms, located within the promoter and intron 1 of the prion protein gene PRNP, showing a significant association with the occurrence of classical form of the disease. Because the effect of the polymorphisms was studied only in few populations, in this study we investigated whether previously described association of PRNP indel polymorphisms with BSE susceptibility in cattle is also present in Polish cattle population. We found a significant relation between the investigated PRNP indel polymorphisms (23 and 12 bp indels), and susceptibility of Polish Holstein-Friesian cattle to classical BSE (P < 0.05). The deletion variants of both polymorphisms were related to increased susceptibility, whereas insertion variants were protective against BSE.

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Year:  2011        PMID： 22170597     DOI： 10.1007/s11033-011-1318-9

Source DB:  PubMed          Journal:  Mol Biol Rep        ISSN： 0301-4851            Impact factor:   2.316


  31 in total

1.  Tissue-specific expression pattern of bovine prion gene: quantification using real-time RT-PCR.

Authors:  Ales Tichopad; Michael W Pfaffl; Andrea Didier
Journal:  Mol Cell Probes       Date:  2003-02       Impact factor: 2.365

2.  Comparison of DNA variants in the PRNP and NF1 regions between bovine spongiform encephalopathy and control cattle.

Authors:  H Geldermann; H He; P Bobal; H Bartenschlager; S Preuss
Journal:  Anim Genet       Date:  2006-10       Impact factor: 3.169

3.  A national survey on the allelic, genotypic, and haplotypic distribution of PRNP insertion and deletion polymorphisms in Korean cattle.

Authors:  Younyoung Kim; Jong Bok Kim; Hyunjoo Sohn; Chaeyoung Lee
Journal:  J Genet       Date:  2009-04       Impact factor: 1.166

4.  Coordinate regulation of bovine prion protein gene promoter activity by two Sp1 binding site polymorphisms.

Authors:  Guangai Xue; Akikazu Sakudo; Chi-kyeong Kim; Takashi Onodera
Journal:  Biochem Biophys Res Commun       Date:  2008-05-27       Impact factor: 3.575

5.  Immunohistochemical detection and localization of prion protein in brain tissue of sheep with natural scrapie.

Authors:  L J van Keulen; B E Schreuder; R H Meloen; M Poelen-van den Berg; G Mooij-Harkes; M E Vromans; J P Langeveld
Journal:  Vet Pathol       Date:  1995-05       Impact factor: 2.221

6.  Prion octapeptide-repeat polymorphism in Polish Black-and-White cattle.

Authors:  Krzysztof Walawski; Urszula Czarnik
Journal:  J Appl Genet       Date:  2003       Impact factor: 3.240

7.  Polymorphisms of Two Indels at the PRNP Gene in Three Beef Cattle Herds.

Authors:  Alexandre R Kerber; Diego Hepp; Daniel T Passos; Tania de Azevedo Weimer
Journal:  Biochem Genet       Date:  2007-12-07       Impact factor: 1.890

8.  Frequencies of PrP gene variants in healthy cattle and cattle with BSE in Scotland.

Authors:  N Hunter; W Goldmann; G Smith; J Hope
Journal:  Vet Rec       Date:  1994-10-22       Impact factor: 2.695

Review 9.  Prions.

Authors:  S B Prusiner
Journal:  Proc Natl Acad Sci U S A       Date:  1998-11-10       Impact factor: 11.205

10.  A major genetic component of BSE susceptibility.

Authors:  Katrin Juling; Hermann Schwarzenbacher; John L Williams; Ruedi Fries
Journal:  BMC Biol       Date:  2006-10-02       Impact factor: 7.431
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  4 in total

1.  PRNP and SPRN genes polymorphism in atypical bovine spongiform encephalopathy cases diagnosed in Polish cattle.

Authors:  Artur Gurgul; Mirosław Paweł Polak; Magdalena Larska; Ewa Słota
Journal:  J Appl Genet       Date:  2012-06-22       Impact factor: 3.240

2.  Exploration of the Main Sites for the Transformation of Normal Prion Protein (PrPC) into Pathogenic Prion Protein (PrPsc).

Authors:  Xi-Lin Liu; Xiao-Li Feng; Guang-Ming Wang; Bin-Bin Gong; Waqas Ahmad; Nan-Nan Liu; Yuan-Yuan Zhang; Li Yang; Hong-Lin Ren; Shu-Sen Cui
Journal:  J Vet Res       Date:  2017-04-04       Impact factor: 1.744

3.  Polymorphisms of shadow of prion protein gene (SPRN) in Korean native cattle (Hanwoo) and Holstein cattle.

Authors:  Yong-Chan Kim; Seon-Kwan Kim; Sae-Young Won; Byung-Hoon Jeong
Journal:  Sci Rep       Date:  2020-09-17       Impact factor: 4.379

4.  Potential scrapie-associated polymorphisms of the prion protein gene (PRNP) in Korean native black goats.

Authors:  Seon-Kwan Kim; Yong-Chan Kim; Sae-Young Won; Byung-Hoon Jeong
Journal:  Sci Rep       Date:  2019-10-25       Impact factor: 4.379
  4 in total

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