Literature DB >> 22169263

Optimization of a novel kinase inhibitor scaffold for the dual inhibition of JAK2 and FAK kinases.

Craig A Zificsak1, Diane E Gingrich, Henry J Breslin, Derek D Dunn, Karen L Milkiewicz, Jay P Theroff, Tho V Thieu, Ted L Underiner, Linda R Weinberg, Lisa D Aimone, Mark S Albom, Jennifer L Mason, Lisa Saville, Jean Husten, Thelma S Angeles, James P Finn, Mahfuza Jan, Teresa M O'Kane, Pawel Dobrzanski, Bruce D Dorsey.   

Abstract

The elaboration of a novel scaffold for the inhibition of JAK2 and FAK kinases was targeted in order to provide a dual inhibitor that could target divergent pathways for tumor cell progression.
Copyright © 2011 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID： 22169263     DOI： 10.1016/j.bmcl.2011.11.049

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  Dual inhibitors of Janus kinase 2 and 3 (JAK2/3): designing by pharmacophore- and docking-based virtual screening approach.

Authors:  Haneesh Jasuja; Navriti Chadha; Maninder Kaur; Om Silakari
Journal:  Mol Divers       Date:  2014-01-11       Impact factor: 2.943

2.  Discovery of antiproliferative and anti-FAK inhibitory activity of 1,2,4-triazole derivatives containing acetamido carboxylic acid skeleton.

Authors:  Muhamad Mustafa; Gamal El-Din A Abuo-Rahma; Amer Ali Abd El-Hafeez; Esam R Ahmed; Dalia Abdelhamid; Pradipta Ghosh; Alaa M Hayallah
Journal:  Bioorg Med Chem Lett       Date:  2021-03-17       Impact factor: 2.823

Review 3.  FAK inhibitors as promising anticancer targets: present and future directions.

Authors:  Muhamad Mustafa; Amer Ali Abd El-Hafeez; Dalia A Abdelhafeez; Dalia Abdelhamid; Yaser A Mostafa; Pradipta Ghosh; Alaa M Hayallah; Gamal El-Din A Abuo-Rahma
Journal:  Future Med Chem       Date:  2021-08-03       Impact factor: 4.767
  3 in total

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