Literature DB >> 22167486

Clonal expansions of CD8⁺ T cells in latently HSV-1-infected human trigeminal ganglia.

Kathrin Held1, Ingrid Eiglmeier, Susanne Himmelein, Inga Sinicina, Thomas Brandt, Diethilde Theil, Klaus Dornmair, Tobias Derfuss.   

Abstract

Herpes simplex virus type 1 latency in trigeminal ganglia (TG) is accompanied by a chronic immune cell infiltration. The aim of this study was to analyse the T-cell receptor β-chain repertoire in latently HSV-1 infected human TG. Using complementarity-determining region 3 spectratyping, 74 expanded β-chain sequences were identified in five TG. No clone appeared in more than one subject. Similar clones were present in the right and the left TG of two subjects. This indicates that these T cells are primed in the periphery and recognise the same antigen in the TG of both sides.

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Year:  2011        PMID： 22167486     DOI： 10.1007/s13365-011-0067-9

Source DB:  PubMed          Journal:  J Neurovirol        ISSN： 1355-0284            Impact factor:   2.643


  21 in total

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4.  Public TCR use by herpes simplex virus-2-specific human CD8 CTLs.

Authors:  Lichun Dong; Penny Li; Tjitske Oenema; Christopher L McClurkan; David M Koelle
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5.  CD8+ T-cell clones dominate brain infiltrates in Rasmussen encephalitis and persist in the periphery.

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Journal:  Immunogenetics       Date:  1995       Impact factor: 2.846

8.  Cross-reactive T-cell receptors in tumor and paraneoplastic target tissue.

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Journal:  Immunol Today       Date:  1995-04

10.  Multiple sclerosis: brain-infiltrating CD8+ T cells persist as clonal expansions in the cerebrospinal fluid and blood.

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Journal:  Proc Natl Acad Sci U S A       Date:  2004-02-24       Impact factor: 11.205
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  12 in total

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Authors:  Arif A Khan; Ruchi Srivastava; Doran Spencer; Sumit Garg; Daniel Fremgen; Hawa Vahed; Patricia P Lopes; Thanh T Pham; Charlie Hewett; Jasmine Kuang; Nicolas Ong; Lei Huang; Vanessa M Scarfone; Anthony B Nesburn; Steven L Wechsler; Lbachir BenMohamed
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4.  Detection of the genome and transcripts of a persistent DNA virus in neuronal tissues by fluorescent in situ hybridization combined with immunostaining.

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5.  The Herpes Simplex Virus Latency-Associated Transcript Gene Is Associated with a Broader Repertoire of Virus-Specific Exhausted CD8+ T Cells Retained within the Trigeminal Ganglia of Latently Infected HLA Transgenic Rabbits.

Authors:  Ruchi Srivastava; Xavier Dervillez; Arif A Khan; Aziz A Chentoufi; Sravya Chilukuri; Nora Shukr; Yasmin Fazli; Nicolas N Ong; Rasha E Afifi; Nelson Osorio; Roger Geertsema; Anthony B Nesburn; Steven L Wechsler; Lbachir BenMohamed
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6.  Phenotypic and Functional Signatures of Herpes Simplex Virus-Specific Effector Memory CD73+CD45RAhighCCR7lowCD8+ TEMRA and CD73+CD45RAlowCCR7lowCD8+ TEM Cells Are Associated with Asymptomatic Ocular Herpes.

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Journal:  J Immunol       Date:  2018-09-10       Impact factor: 5.422

7.  Influence of an immunodominant herpes simplex virus type 1 CD8+ T cell epitope on the target hierarchy and function of subdominant CD8+ T cells.

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9.  Local CD4 and CD8 T-cell reactivity to HSV-1 antigens documents broad viral protein expression and immune competence in latently infected human trigeminal ganglia.

Authors:  Monique van Velzen; Lichen Jing; Albert D M E Osterhaus; Alessandro Sette; David M Koelle; Georges M G M Verjans
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10.  Virus-specific immune memory at peripheral sites of herpes simplex virus type 2 (HSV-2) infection in guinea pigs.

Authors:  Jingya Xia; Ronald L Veselenak; Summer R Gorder; Nigel Bourne; Gregg N Milligan
Journal:  PLoS One       Date:  2014-12-08       Impact factor: 3.240
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