Literature DB >> 22167417

Development and characterization of zein-based microcarrier system for sustained delivery of aceclofenac sodium.

K Karthikeyan1, Rachita Lakra, Rama Rajaram, Purna Sai Korrapati.   

Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs) induce gastric injury on long-term usage. This study aims at reducing the side effect of NSAIDs by encapsulating in zein, an acid-resistant biopolymer. Aceclofenac-loaded zein microspheres were prepared by emulsification and solvent evaporation method. The stability of zein microspheres at gastric pH retarded the release of the entrapped drug and hence reduces the possibility of gastric injury. However, the in vitro release of aceclofenac was sustained up to 72 h at intestinal pH. Thus, zein microspheres pave the way for the development of safe and sustained delivery system for NSAIDs thereby achieving the desired therapeutic potential with reduced side effects for chronic inflammatory disorders.

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Year:  2011        PMID： 22167417      PMCID： PMC3299440          DOI： 10.1208/s12249-011-9731-x

Source DB:  PubMed          Journal:  AAPS PharmSciTech        ISSN： 1530-9932            Impact factor:   3.246


  10 in total

1.  Lysozyme distribution and conformation in a biodegradable polymer matrix as determined by FTIR techniques.

Authors:  M van de Weert; R van 't Hof1; J van der Weerd; R M Heeren; G Posthuma; W E Hennink; D J Crommelin
Journal:  J Control Release       Date:  2000-07-31       Impact factor: 9.776

2.  Basic study of corn protein, zein, as a biomaterial in tissue engineering, surface morphology and biocompatibility.

Authors:  Jian Dong; Qingshen Sun; Jin-Ye Wang
Journal:  Biomaterials       Date:  2004-08       Impact factor: 12.479

3.  Microspheres of corn protein, zein, for an ivermectin drug delivery system.

Authors:  Xinming Liu; Qingshen Sun; Huajie Wang; Lei Zhang; J-Y Jin-Ye Wang
Journal:  Biomaterials       Date:  2005-01       Impact factor: 12.479

4.  Heparin-loaded zein microsphere film and hemocompatibility.

Authors:  Hua-Jie Wang; Zhi-Xin Lin; Xin-Ming Liu; Shi-Yan Sheng; Jin-Ye Wang
Journal:  J Control Release       Date:  2005-06-20       Impact factor: 9.776

5.  Simple coacervates of zein to encapsulate Gitoxin.

Authors:  L Muthuselvi; Aruna Dhathathreyan
Journal:  Colloids Surf B Biointerfaces       Date:  2006-05-26       Impact factor: 5.268

6.  Preparation and evaluation of Eudragit S 100 microspheres as pH-sensitive release preparations for piroxicam and theophylline using the emulsion-solvent evaporation method.

Authors:  Wasfy M Obeidat; James C Price
Journal:  J Microencapsul       Date:  2006-03       Impact factor: 3.142

7.  Zein microspheres as drug/antigen carriers: a study of their degradation and erosion, in the presence and absence of enzymes.

Authors:  Pepi Hurtado-López; Sudax Murdan
Journal:  J Microencapsul       Date:  2006-05       Impact factor: 3.142

8.  Management of NSAID induced gastrointestinal disturbance.

Authors:  M Doherty; R H Hunt; M J Langman; R E Pounder; R I Russell; R D Sturrock; A K Thould
Journal:  Ann Rheum Dis       Date:  1987-08       Impact factor: 19.103

9.  Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.

Authors:  T Mosmann
Journal:  J Immunol Methods       Date:  1983-12-16       Impact factor: 2.303

Review 10.  Microencapsulation by solvent evaporation: state of the art for process engineering approaches.

Authors:  Ming Li; Olivier Rouaud; Denis Poncelet
Journal:  Int J Pharm       Date:  2008-07-29       Impact factor: 5.875
  10 in total
  9 in total

1.  Chitosan-zein nano-in-microparticles capable of mediating in vivo transgene expression following oral delivery.

Authors:  Eric Farris; Deborah M Brown; Amanda E Ramer-Tait; Angela K Pannier
Journal:  J Control Release       Date:  2017-01-31       Impact factor: 9.776

2.  Zein/polycaprolactone electrospun matrices for localised controlled delivery of tetracycline.

Authors:  Nour Alhusein; Ian S Blagbrough; Paul A De Bank
Journal:  Drug Deliv Transl Res       Date:  2013-12       Impact factor: 4.617

3.  Selective interactions of zein microspheres with different class of drugs: an in vitro and in silico analysis.

Authors:  K Karthikeyan; Ezhilarasan Vijayalakshmi; Purna Sai Korrapati
Journal:  AAPS PharmSciTech       Date:  2014-05-30       Impact factor: 3.246

4.  Rational Fabrication of Folate-Conjugated Zein/Soy Lecithin/Carboxymethyl Chitosan Core-Shell Nanoparticles for Delivery of Docetaxel.

Authors:  Zhenyao Wu; Jie Li; Xin Zhang; Yangjia Li; Dongwei Wei; Lichang Tang; Shiming Deng; Guijin Liu
Journal:  ACS Omega       Date:  2022-04-07

Review 5.  Zein Microparticles and Nanoparticles as Drug Delivery Systems.

Authors:  Iolanda De Marco
Journal:  Polymers (Basel)       Date:  2022-05-27       Impact factor: 4.967

6.  Size-controlled fabrication of zein nano/microparticles by modified anti-solvent precipitation with/without sodium caseinate.

Authors:  Feng Li; Yan Chen; Shubo Liu; Jian Qi; Weiying Wang; Chenhua Wang; Ruiyue Zhong; Zhijun Chen; Xiaoming Li; Yuanzhou Guan; Wei Kong; Yong Zhang
Journal:  Int J Nanomedicine       Date:  2017-11-10

7.  Production of carrier/antioxidant particles by Supercritical Assisted Atomization as an adjuvant treatment of the CoVID-19 pathology.

Authors:  Iolanda De Marco
Journal:  J Supercrit Fluids       Date:  2022-04-09       Impact factor: 4.514

Review 8.  Zein-based nano-delivery systems for encapsulation and protection of hydrophobic bioactives: A review.

Authors:  Xiaojia Yan; Moting Li; Xingfeng Xu; Xuebo Liu; Fuguo Liu
Journal:  Front Nutr       Date:  2022-09-28

9.  Assessment of the dose-dependent biochemical and cytotoxicity of zein-coated MgO nanowires in male and female albino rats.

Authors:  Ghada H Naguib; Gamal S Abd El-Aziz; Hisham A Mously; Sahar M Bukhary; Mohamed T Hamed
Journal:  Ann Med       Date:  2021-12       Impact factor: 4.709
  9 in total

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