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Literature DB >> 22167237

Moderate or deep local hypothermia does not prevent the onset of ischemia-induced dendritic damage.

Sherri Tran¹, Shangbin Chen, Ran R Liu, Yicheng Xie, Timothy H Murphy.

Abstract

We studied the acute (up to 2 hours after reperfusion) effects of localized cortical hypothermia on ischemia-induced dendritic structural damage. Moderate (31°C) and deep (22°C) hypothermia delays, but does not block the onset of dendritic blebbing or spine loss during global ischemia in mouse in vivo. Hypothermic treatment promoted more consistent recovery of dendritic structure and spines during reperfusion. These results suggest that those using therapeutic hypothermia will need to consider that it does not spare neurons from structural changes that are the result of ischemia, but hypothermia may interact with mechanisms that control the onset of damage and recovery during reperfusion.

Entities: Disease Species

Mesh：

Year: 2011 PMID： 22167237 PMCID： PMC3293122 DOI： 10.1038/jcbfm.2011.178

Source DB: PubMed Journal: J Cereb Blood Flow Metab ISSN： 0271-678X Impact factor: 6.200

14 in total

1. Dendritic spines disappear with chilling but proliferate excessively upon rewarming of mature hippocampus.

Authors: S A Kirov; L J Petrak; J C Fiala; K M Harris
Journal: Neuroscience Date: 2004 Impact factor: 3.590

2. Automated and quantitative image analysis of ischemic dendritic blebbing using in vivo 2-photon microscopy data.

Authors: Shangbin Chen; Sherri Tran; Albrecht Sigler; Timothy H Murphy
Journal: J Neurosci Methods Date: 2010-12-22 Impact factor: 2.390

Review 3. Postischemic hypothermia. A critical appraisal with implications for clinical treatment.

Authors: F Colbourne; G Sutherland; D Corbett
Journal: Mol Neurobiol Date: 1997-06 Impact factor: 5.590

4. Electron microscopic evidence against apoptosis as the mechanism of neuronal death in global ischemia.

Authors: F Colbourne; G R Sutherland; R N Auer
Journal: J Neurosci Date: 1999-06-01 Impact factor: 6.167

5. Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia.

Authors: Stephen A Bernard; Timothy W Gray; Michael D Buist; Bruce M Jones; William Silvester; Geoff Gutteridge; Karen Smith
Journal: N Engl J Med Date: 2002-02-21 Impact factor: 91.245

6. Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP.

Authors: G Feng; R H Mellor; M Bernstein; C Keller-Peck; Q T Nguyen; M Wallace; J M Nerbonne; J W Lichtman; J R Sanes
Journal: Neuron Date: 2000-10 Impact factor: 17.173

7. Glutamate does not mediate acute neuronal damage after spreading depression induced by O2/glucose deprivation in the hippocampal slice.

Authors: A S Obeidat; C R Jarvis; R D Andrew
Journal: J Cereb Blood Flow Metab Date: 2000-02 Impact factor: 6.200

3. Differential Tiam1/Rac1 activation in hippocampal and cortical neurons mediates differential spine shrinkage in response to oxygen/glucose deprivation.

Authors: Elena Blanco-Suárez; Maria Fiuza; Xun Liu; Elavazhagan Chakkarapani; Jonathan G Hanley
Journal: J Cereb Blood Flow Metab Date: 2014-09-24 Impact factor: 6.200

3 in total

Moderate or deep local hypothermia does not prevent the onset of ischemia-induced dendritic damage.

1. Dendritic spines disappear with chilling but proliferate excessively upon rewarming of mature hippocampus.

2. Automated and quantitative image analysis of ischemic dendritic blebbing using in vivo 2-photon microscopy data.

Review 3. Postischemic hypothermia. A critical appraisal with implications for clinical treatment.

4. Electron microscopic evidence against apoptosis as the mechanism of neuronal death in global ischemia.

5. Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia.

6. Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP.

7. Glutamate does not mediate acute neuronal damage after spreading depression induced by O2/glucose deprivation in the hippocampal slice.

8. Brain damage in a mouse model of global cerebral ischemia. Effect of NMDA receptor blockade.

9. A model of global cerebral ischemia in C57 BL/6 mice.

Review 10. General versus specific actions of mild-moderate hypothermia in attenuating cerebral ischemic damage.

1. In vivo imaging with a water immersion objective affects brain temperature, blood flow and oxygenation.

2. Dendritic spines and pre-synaptic boutons are stable despite local deep hypothermic challenge and re-warming in vivo.

3. Differential Tiam1/Rac1 activation in hippocampal and cortical neurons mediates differential spine shrinkage in response to oxygen/glucose deprivation.