Literature DB >> 22165988

Delivery of multiple siRNAs using lipid-coated PLGA nanoparticles for treatment of prostate cancer.

Warefta Hasan1, Kevin Chu, Anuradha Gullapalli, Stuart S Dunn, Elizabeth M Enlow, J Christopher Luft, Shaomin Tian, Mary E Napier, Patrick D Pohlhaus, Jason P Rolland, Joseph M DeSimone.   

Abstract

Nanotechnology can provide a critical advantage in developing strategies for cancer management and treatment by helping to improve the safety and efficacy of novel therapeutic delivery vehicles. This paper reports the fabrication of poly(lactic acid-co-glycolic acid)/siRNA nanoparticles coated with lipids for use as prostate cancer therapeutics made via a unique soft lithography particle molding process called Particle Replication In Nonwetting Templates (PRINT). The PRINT process enables high encapsulation efficiency of siRNA into neutral and monodisperse PLGA particles (32-46% encapsulation efficiency). Lipid-coated PLGA/siRNA PRINT particles were used to deliver therapeutic siRNA in vitro to knockdown genes relevant to prostate cancer.
© 2011 American Chemical Society

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Year:  2011        PMID： 22165988      PMCID： PMC3358784          DOI： 10.1021/nl2035354

Source DB:  PubMed          Journal:  Nano Lett        ISSN： 1530-6984            Impact factor:   11.189


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