BACKGROUND: Data on conversion ratios for switching opioids in substitution treatment are limited. METHODS: Data were obtained from a randomized controlled trial among long-term opioid-dependent patients conducted in Vancouver and Montreal, Canada. Patients received diacetylmorphine (n = 115) or hydromorphone (n = 25) on a double-blind basis, on a 1:3 potency ratio with individually adjusted dosage, both injectable. RESULTS: Average daily dosages of hydromorphone and diacetylmorphine prescribed were 212.6 mg and 454.0 mg, respectively; potency ratio was 1:2.0-2.2 at different dose ranges. CONCLUSIONS: Studies using hydromorphone as a diacetylmorphine equivalent should consider the ratio found in this study to achieve equipotency and maintain the blinding.
RCT Entities:
BACKGROUND: Data on conversion ratios for switching opioids in substitution treatment are limited. METHODS: Data were obtained from a randomized controlled trial among long-term opioid-dependent patients conducted in Vancouver and Montreal, Canada. Patients received diacetylmorphine (n = 115) or hydromorphone (n = 25) on a double-blind basis, on a 1:3 potency ratio with individually adjusted dosage, both injectable. RESULTS: Average daily dosages of hydromorphone and diacetylmorphine prescribed were 212.6 mg and 454.0 mg, respectively; potency ratio was 1:2.0-2.2 at different dose ranges. CONCLUSIONS: Studies using hydromorphone as a diacetylmorphine equivalent should consider the ratio found in this study to achieve equipotency and maintain the blinding.
Authors: Kirsten I Marchand; Eugenia Oviedo-Joekes; Daphne Guh; Suzanne Brissette; David C Marsh; Martin T Schechter Journal: BMC Health Serv Res Date: 2011-07-26 Impact factor: 2.655
Authors: Eugenia Oviedo-Joekes; Heather Palis; Daphne Guh; David C Marsh; Scott MacDonald; Scott Harrison; Suzanne Brissette; Aslam H Anis; Martin T Schechter Journal: J Addict Med Date: 2019 Sep/Oct Impact factor: 3.702