[Screening and characteristics of regulators of landomycin E biosynthesis in Streptomyces globisporus].

The screening of the positive regulators of landomycin E biosynthesis has been conducted among exogenous metabolites of the museum and freshly isolated Streptomycetes strains by means of cosynthesis test using mutant strain Streptomyces globisporus 1912-82. The ability to produce the exogenous metabolites restoring landomycin E biosynthesis by B2 strain was shown. The regulatory compounds purified by thin-layer chromatography differed between themselves by chromatographic mobility (Rf) and maxima of absorption in UV-light. They were divided into four types of extracellular regulators of landomycin E biosynthesis on the basis of preliminary study.