| Literature DB >> 22162905 |
Dianhua Jiang1, Jiurong Liang, Rishu Guo, Ting Xie, Francine L Kelly, Tereza Martinu, Ting Yang, Alysia K Lovgren, Jessica Chia, Ningshan Liu, Yoosun Jung, Scott M Palmer, Paul W Noble.
Abstract
Chemokines and chemokine receptors have been implicated in the pathogenesis of bronchiolitis. CXCR3 ligands (CXCL10, CXCL9, and CXCL11) were elevated in patients with bronchiolitis obliterans syndrome (BOS) and chronic allorejection. Studies also suggested that blockage of CXCR3 or its ligands changed the outcome of T-cell recruitment and airway obliteration. We wanted to determine the role of the chemokine CXCL10 in the pathogenesis of bronchiolitis and BOS. In this study, we found that CXCL10 mRNA levels were significantly increased in patients with BOS. We generated transgenic mice expressing a mouse CXCL10 cDNA under control of the rat CC10 promoter. Six-month-old CC10-CXCL10 transgenic mice developed bronchiolitis characterized by airway epithelial hyperplasia and developed peribronchiolar and perivascular lymphocyte infiltration. The airway hyperplasia and T-cell inflammation were dependent on the presence of CXCR3. Therefore, long-term exposure of the chemokine CXCL10 in the lung causes bronchiolitis-like inflammation in mice.Entities:
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Year: 2011 PMID： 22162905 PMCID： PMC3359901 DOI： 10.1165/rcmb.2011-0116OC
Source DB: PubMed Journal: Am J Respir Cell Mol Biol ISSN： 1044-1549 Impact factor: 6.914