Literature DB >> 22161122

Combining click-multicomponent reaction: one-pot synthesis of triazolyl methoxy-phenyl indazolo[2,1-b]phthalazine-trione derivatives.

Peyman Salehi1, David I MaGee, Minoo Dabiri, Laleh Torkian, Jordan Donahue.   

Abstract

[(1,2,3-Triazol-4-yl)methoxy-phenyl]-2H-indazolo[2,1-b]phthalazine-trione derivatives were synthesized in a simple and efficient method from the one-pot four-component condensation reaction of phthalhydrazide, aromatic propargyloxy aldehydes, active methylene compounds (dimedone and 1,3-cyclohexanedione), and azides in the presence of Cu(OAc)(2)/sodium ascorbate and p-toluenesulfonic acid as catalysts in good to excellent yields.

Entities:  

Mesh:

Substances:

Year:  2011        PMID: 22161122     DOI: 10.1007/s11030-011-9348-8

Source DB:  PubMed          Journal:  Mol Divers        ISSN: 1381-1991            Impact factor:   2.943


  18 in total

1.  Click Chemistry: Diverse Chemical Function from a Few Good Reactions.

Authors:  Hartmuth C. Kolb; M. G. Finn; K. Barry Sharpless
Journal:  Angew Chem Int Ed Engl       Date:  2001-06-01       Impact factor: 15.336

Review 2.  "Multi-component reactions : emerging chemistry in drug discovery" 'from xylocain to crixivan'.

Authors:  Christopher Hulme; Vijay Gore
Journal:  Curr Med Chem       Date:  2003-01       Impact factor: 4.530

3.  In situ click chemistry: a powerful means for lead discovery.

Authors:  K Barry Sharpless; Roman Manetsch
Journal:  Expert Opin Drug Discov       Date:  2006-11       Impact factor: 6.098

4.  Synthesis and anticonvulsant activity of novel and potent 6,7-methylenedioxyphthalazin-1(2H)-ones.

Authors:  S Grasso; G De Sarro; A De Sarro; N Micale; M Zappalà; G Puja; M Baraldi; C De Micheli
Journal:  J Med Chem       Date:  2000-07-27       Impact factor: 7.446

5.  Substituent effects on the antibacterial activity of nitrogen-carbon-linked (azolylphenyl)oxazolidinones with expanded activity against the fastidious gram-negative organisms Haemophilus influenzae and Moraxella catarrhalis.

Authors:  M J Genin; D A Allwine; D J Anderson; M R Barbachyn; D E Emmert; S A Garmon; D R Graber; K C Grega; J B Hester; D K Hutchinson; J Morris; R J Reischer; C W Ford; G E Zurenko; J C Hamel; R D Schaadt; D Stapert; B H Yagi
Journal:  J Med Chem       Date:  2000-03-09       Impact factor: 7.446

6.  Combining Biginelli multicomponent and click chemistry: generation of 6-(1,2,3-triazol-1-yl)-dihydropyrimidone libraries.

Authors:  Bogdan Khanetskyy; Doris Dallinger; C Oliver Kappe
Journal:  J Comb Chem       Date:  2004 Nov-Dec

Review 7.  The growing applications of click chemistry.

Authors:  John E Moses; Adam D Moorhouse
Journal:  Chem Soc Rev       Date:  2007-05-03       Impact factor: 54.564

8.  Ultrasound-assisted one-pot, three-component synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones.

Authors:  Mohammad Reza Nabid; Seyed Jamal Tabatabaei Rezaei; Ramin Ghahremanzadeh; Ayoob Bazgir
Journal:  Ultrason Sonochem       Date:  2009-06-18       Impact factor: 7.491

9.  Studies on 1,2,3-triazoles. 13. (Piperazinylalkoxy) [1]benzopyrano[2,3-d]-1,2,3-triazol-9(1H)-ones with combined H1-antihistamine and mast cell stabilizing properties.

Authors:  D R Buckle; C J Rockell; H Smith; B A Spicer
Journal:  J Med Chem       Date:  1986-11       Impact factor: 7.446

10.  1,2,3-Triazole-[2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D- ribofuranosyl]-3'-spiro-5"-(4"-amino-1",2"-oxathiole 2",2"-dioxide) (TSAO) analogues: synthesis and anti-HIV-1 activity.

Authors:  R Alvarez; S Velázquez; A San-Félix; S Aquaro; E De Clercq; C F Perno; A Karlsson; J Balzarini; M J Camarasa
Journal:  J Med Chem       Date:  1994-11-25       Impact factor: 7.446

View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.