Literature DB >> 22159592

Synthesis of 1,3,4-oxadiazoles from 1,2-diacylhydrazines using [Et2NSF2]BF4 as a practical cyclodehydration agent.

Marie-France Pouliot1, Laetitia Angers, Jean-Denys Hamel, Jean-François Paquin.   

Abstract

The preparation of 1,3,4-oxadiazoles from 1,2-diacylhydrazines using XtalFluor-E ([Et(2)NSF(2)]BF(4)) as cyclodehydration reagent is described. Various functionalized 1,3,4-oxadiazoles were synthesized and it was found that the use of acetic acid as an additive generally improved the yields.

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Year:  2011        PMID： 22159592     DOI： 10.1039/c1ob06512b

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  6 in total

1.  Total Synthesis of Mycobacterium tuberculosis Dideoxymycobactin-838 and Stereoisomers: Diverse CD1a-Restricted T Cells Display a Common Hierarchy of Lipopeptide Recognition.

Authors:  Janice M H Cheng; Ligong Liu; Daniel G Pellicci; Scott J J Reddiex; Rachel N Cotton; Tan-Yun Cheng; David C Young; Ildiko Van Rhijn; D Branch Moody; Jamie Rossjohn; David P Fairlie; Dale I Godfrey; Spencer J Williams
Journal:  Chemistry       Date:  2017-01-18       Impact factor: 5.236

Review 2.  Comparative Study of the Synthetic Approaches and Biological Activities of the Bioisosteres of 1,3,4-Oxadiazoles and 1,3,4-Thiadiazoles over the Past Decade.

Authors:  Rana M El-Masry; Hanan H Kadry; Azza T Taher; Sahar M Abou-Seri
Journal:  Molecules       Date:  2022-04-22       Impact factor: 4.927

3.  Design, synthesis and characterization of novel 1,2-benzisothiazol-3(2H)-one and 1,3,4-oxadiazole hybrid derivatives: potent inhibitors of Dengue and West Nile virus NS2B/NS3 proteases.

Authors:  Huiguo Lai; Dengfeng Dou; Sridhar Aravapalli; Tadahisa Teramoto; Gerald H Lushington; Tom M Mwania; Kevin R Alliston; David M Eichhorn; Radhakrishnan Padmanabhan; William C Groutas
Journal:  Bioorg Med Chem       Date:  2012-11-15       Impact factor: 3.641

4.  Electrophilic activation of nitroalkanes in efficient synthesis of 1,3,4-oxadiazoles.

Authors:  Alexander V Aksenov; Vladislav Khamraev; Nicolai A Aksenov; Nikita K Kirilov; Dmitriy A Domenyuk; Vladimir A Zelensky; Michael Rubin
Journal:  RSC Adv       Date:  2019-02-26       Impact factor: 3.361

5.  Synthesis of 2-Imino-1,3,4-oxadiazolines from Acylhydrazides and Isothiocyanates via Aerobic Oxidation and a DMAP-Mediated Annulation Sequence.

Authors:  Jae Hyeok Lim; Sang Eun Baek; Bapurao Sudam Lad; Jinho Kim
Journal:  ACS Omega       Date:  2022-08-01

Review 6.  Synthetic approaches and pharmacological activity of 1,3,4-oxadiazoles: a review of the literature from 2000-2012.

Authors:  Cledualdo Soares de Oliveira; Bruno Freitas Lira; José Maria Barbosa-Filho; Jorge Gonçalo Fernandez Lorenzo; Petrônio Filgueiras de Athayde-Filho
Journal:  Molecules       Date:  2012-08-27       Impact factor: 4.411
  6 in total

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