Literature DB >> 22158888

The effects of single doses of alpidem and lorazepam on memory and psychomotor performance in normal humans.

H V Curran1, D Allen, M Lader.   

Abstract

Two studies are reported which compare different single doses of alpidem (SL80.0343-00) with lorazepam 2 mg. In the first study, lorazepam and the highest (100 mg) dose of alpidem impaired performance on a range of psychomotor tasks, although the effects of lorazepam were more severe and persisted for longer than those of alpidem. In comparison, alpidem 50 and 25 mg had little effect. The EEG profiles of both drugs were similar.

Entities:  

Year:  1987        PMID： 22158888     DOI： 10.1177/026988118700100204

Source DB:  PubMed          Journal:  J Psychopharmacol        ISSN： 0269-8811            Impact factor:   4.153


  8 in total

1.  Clinical pharmacokinetics and tolerability of alpidem in healthy subjects given increasing single doses.

Authors:  J H Jonkman; G Bianchetti; G Grasmeijer; B Oosterhuis; J F Thiercelin; J P Thénot; P Guillet; P L Morselli
Journal:  Eur J Clin Pharmacol       Date:  1991       Impact factor: 2.953

2.  Plasma protein binding of alpidem in healthy volunteers, in neonates and in liver or renal insufficiency.

Authors:  G M Pacifici; G Bianchetti; A Viani; G Rizzo; M Carrai; J Allen; P L Morselli
Journal:  Eur J Clin Pharmacol       Date:  1989       Impact factor: 2.953

Review 3.  Benzodiazepines, memory and mood: a review.

Authors:  H V Curran
Journal:  Psychopharmacology (Berl)       Date:  1991       Impact factor: 4.530

4.  Memory and psychomotor effects of oxcarbazepine in healthy human volunteers.

Authors:  H V Curran; R Java
Journal:  Eur J Clin Pharmacol       Date:  1993       Impact factor: 2.953

5.  The cognitive and psychomotor effects of opioid analgesics. II. A randomized controlled trial of single doses of morphine, lorazepam and placebo in healthy subjects.

Authors:  G W Hanks; W M O'Neill; P Simpson; K Wesnes
Journal:  Eur J Clin Pharmacol       Date:  1995       Impact factor: 2.953

6.  The cognitive and psychomotor effects of opioid analgesics. I. A randomized controlled trial of single doses of dextropropoxyphene, lorazepam and placebo in healthy subjects.

Authors:  W M O'Neill; G W Hanks; L White; P Simpson; K Wesnes
Journal:  Eur J Clin Pharmacol       Date:  1995       Impact factor: 2.953

7.  Characterizing the subjective, psychomotor, and physiological effects of oral oxycodone in non-drug-abusing volunteers.

Authors:  James P Zacny; Sandra Gutierrez
Journal:  Psychopharmacology (Berl)       Date:  2003-08-29       Impact factor: 4.530

8.  Individual Differences in Working Memory Capacity Predict Topiramate-Related Cognitive Deficits.

Authors:  Christopher M Barkley; Zhenhong Hu; Ann M Fieberg; Lynn E Eberly; Angela K Birnbaum; Ilo E Leppik; Susan E Marino
Journal:  J Clin Psychopharmacol       Date:  2018-10       Impact factor: 3.153
  8 in total

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