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Literature DB >> 22158605

The AhR-Nrf2 pathway in keratinocytes: on the road to chemoprevention?

Thomas Haarmann-Stemmann¹, Josef Abel, Ellen Fritsche, Jean Krutmann.

Abstract

The ligand-activated transcription factor AhR mediates the cutaneous stress response toward a variety of environmental noxae and is therefore currently of interest for modern preventive medicine. In this issue, Tsuji et al. identify the antifungal agent ketoconazole as an inducer of AhR signaling and the Nrf2 antioxidant response in human keratinocytes. Ketoconazole-stimulated nuclear translocation of Nrf2 and its cytoprotective effects against oxidative stress strongly depend on a functional AhR. This newly identified AhR-Nrf2 pathway opens up new opportunities to prevent and treat inflammatory skin diseases.

Entities: Chemical Disease Gene Species

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Year: 2012 PMID： 22158605 DOI： 10.1038/jid.2011.359

Source DB: PubMed Journal: J Invest Dermatol ISSN： 0022-202X Impact factor: 8.551

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Cited

32 in total

1. The new aryl hydrocarbon receptor antagonist E/Z-2-benzylindene-5,6-dimethoxy-3,3-dimethylindan-1-one protects against UVB-induced signal transduction.

Authors: Julia Tigges; Thomas Haarmann-Stemmann; Christoph F A Vogel; Annemarie Grindel; Ulrike Hübenthal; Heidi Brenden; Susanne Grether-Beck; Gabriele Vielhaber; William Johncock; Jean Krutmann; Ellen Fritsche
Journal: J Invest Dermatol Date: 2013-08-30 Impact factor: 8.551

2. PCB 126 induces monocyte/macrophage polarization and inflammation through AhR and NF-κB pathways.

Authors: Chunyan Wang; Michael C Petriello; Beibei Zhu; Bernhard Hennig
Journal: Toxicol Appl Pharmacol Date: 2019-02-13 Impact factor: 4.219

3. Effects of glutamate on growth, antioxidant capacity, and antioxidant-related signaling molecule expression in primary cultures of fish enterocytes.

Authors: Jun Jiang; Dan Shi; Xiao-Qiu Zhou; Long Yin; Lin Feng; Yang Liu; Wei-Dan Jiang; Ye Zhao
Journal: Fish Physiol Biochem Date: 2015-05-22 Impact factor: 2.794

4. Pivotal role of the aryl hydrocarbon receptor in modulations caused by benzo[a]pyrene and ketoconazole in the estrogenic responses induced by 17β-estradiol in male goldfish.

Authors: Zdenek Dvorak
Journal: Environ Sci Pollut Res Int Date: 2016-03-08 Impact factor: 4.223

Review 5. Aryl Hydrocarbon Receptor in Oxidative Stress as a Double Agent and Its Biological and Therapeutic Significance.

Authors: Alevtina Y Grishanova; Maria L Perepechaeva
Journal: Int J Mol Sci Date: 2022-06-16 Impact factor: 6.208

6. Coal tar induces AHR-dependent skin barrier repair in atopic dermatitis.

Authors: Ellen H van den Bogaard; Judith G M Bergboer; Mieke Vonk-Bergers; Ivonne M J J van Vlijmen-Willems; Stanleyson V Hato; Pieter G M van der Valk; Jens Michael Schröder; Irma Joosten; Patrick L J M Zeeuwen; Joost Schalkwijk
Journal: J Clin Invest Date: 2013-01-25 Impact factor: 14.808

The AhR-Nrf2 pathway in keratinocytes: on the road to chemoprevention?

1. The new aryl hydrocarbon receptor antagonist E/Z-2-benzylindene-5,6-dimethoxy-3,3-dimethylindan-1-one protects against UVB-induced signal transduction.

2. PCB 126 induces monocyte/macrophage polarization and inflammation through AhR and NF-κB pathways.

3. Effects of glutamate on growth, antioxidant capacity, and antioxidant-related signaling molecule expression in primary cultures of fish enterocytes.

4. Pivotal role of the aryl hydrocarbon receptor in modulations caused by benzo[a]pyrene and ketoconazole in the estrogenic responses induced by 17β-estradiol in male goldfish.

Review 5. Aryl Hydrocarbon Receptor in Oxidative Stress as a Double Agent and Its Biological and Therapeutic Significance.

6. Coal tar induces AHR-dependent skin barrier repair in atopic dermatitis.

7. Modulation of keratinocyte expression of antioxidants by 4-hydroxynonenal, a lipid peroxidation end product.

8. Effects of anthocyanins on the AhR-CYP1A1 signaling pathway in human hepatocytes and human cancer cell lines.

Review 9. Functions of the aryl hydrocarbon receptor in the skin.

Review 10. Toxicological function of adipose tissue: focus on persistent organic pollutants.