| Literature DB >> 22158540 |
Chen Wu1, Xiaoping Miao, Liming Huang, Xu Che, Guoliang Jiang, Dianke Yu, Xianghong Yang, Guangwen Cao, Zhibin Hu, Yongjian Zhou, Chaohui Zuo, Chunyou Wang, Xianghong Zhang, Yifeng Zhou, Xianjun Yu, Wanjin Dai, Zhaoshen Li, Hongbing Shen, Luming Liu, Yanling Chen, Sheng Zhang, Xiaoqi Wang, Kan Zhai, Jiang Chang, Yu Liu, Menghong Sun, Wei Cao, Jun Gao, Ying Ma, Xiongwei Zheng, Siu Tim Cheung, Yongfeng Jia, Jian Xu, Wen Tan, Ping Zhao, Tangchun Wu, Chengfeng Wang, Dongxin Lin.
Abstract
Pancreatic cancer has the lowest survival rate among human cancers, and there are no effective markers for its screening and early diagnosis. To identify genetic susceptibility markers for this cancer, we carried out a genome-wide association study on 981 individuals with pancreatic cancer (cases) and 1,991 cancer-free controls of Chinese descent using 666,141 autosomal SNPs. Promising associations were replicated in an additional 2,603 pancreatic cancer cases and 2,877 controls recruited from 25 hospitals in 16 provinces or cities in China. We identified five new susceptibility loci at chromosomes 21q21.3, 5p13.1, 21q22.3, 22q13.32 and 10q26.11 (P = 2.24 × 10(-13) to P = 4.18 × 10(-10)) in addition to 13q22.1 previously reported in populations of European ancestry. These results advance our understanding of the development of pancreatic cancer and highlight potential targets for the prevention or treatment of this cancer.Entities:
Mesh：
Year: 2011 PMID： 22158540 DOI： 10.1038/ng.1020
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330