AIM: The aim of this study was to compare the diagnostic performance of whole-body bone scintigraphy (WBS) and multi-field-of-view single photon emission tomography (multi-FOV SPECT) with 99mTc-oxidronate (99mTc-HDP) in patients with prostate cancer (PCa). METHODS: In a prospective study, WBS and SPECT acquisitions were performed in 194 patients with histologically confirmed PCa and serum prostate-specific antigen (PSA) levels above 10 ng/mL. Scans obtained using the two modalities were interpreted separately. Clinical and biochemical follow-up, radiological studies and biopsies served as benchmarks for the assessments. The impact of PSA level on WBS and SPECT results was also evaluated. RESULTS: The patient-based sensitivity, specificity, accuracy, PPV and NPV values of SPECT examinations were higher than those of WBS, especially in patients with serum PSA levels <40 ng/mL. CONCLUSION: Multi-FOV SPECT proved to be more sensitive and specific than WBS in detecting bone metastases in PCa patients.
AIM: The aim of this study was to compare the diagnostic performance of whole-body bone scintigraphy (WBS) and multi-field-of-view single photon emission tomography (multi-FOV SPECT) with 99mTc-oxidronate (99mTc-HDP) in patients with prostate cancer (PCa). METHODS: In a prospective study, WBS and SPECT acquisitions were performed in 194 patients with histologically confirmed PCa and serum prostate-specific antigen (PSA) levels above 10 ng/mL. Scans obtained using the two modalities were interpreted separately. Clinical and biochemical follow-up, radiological studies and biopsies served as benchmarks for the assessments. The impact of PSA level on WBS and SPECT results was also evaluated. RESULTS: The patient-based sensitivity, specificity, accuracy, PPV and NPV values of SPECT examinations were higher than those of WBS, especially in patients with serum PSA levels <40 ng/mL. CONCLUSION: Multi-FOV SPECT proved to be more sensitive and specific than WBS in detecting bone metastases in PCa patients.
Authors: Steven P Rowe; Margarita Mana-Ay; Mehrbod S Javadi; Zsolt Szabo; Jeffrey P Leal; Martin G Pomper; Kenneth J Pienta; Ashley E Ross; Michael A Gorin Journal: Clin Genitourin Cancer Date: 2015-09-30 Impact factor: 2.872
Authors: Catherine Guezennec; Nathalie Keromnes; Philippe Robin; Ronan Abgral; David Bourhis; Solène Querellou; Romain de Laroche; Alexandra Le Duc-Pennec; Pierre-Yves Salaün; Pierre-Yves Le Roux Journal: Cancer Imaging Date: 2017-06-07 Impact factor: 3.909