Literature DB >> 22157867

Phospholipase D as a therapeutic target in brain disorders.

Craig W Lindsley1, H Alex Brown.   

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Year:  2012        PMID： 22157867      PMCID： PMC3238067          DOI： 10.1038/npp.2011.178

Source DB:  PubMed          Journal:  Neuropsychopharmacology        ISSN： 0893-133X            Impact factor:   7.853


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  6 in total

1.  Design, synthesis, and biological evaluation of halogenated N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)benzamides: discovery of an isoform-selective small molecule phospholipase D2 inhibitor.

Authors:  Robert R Lavieri; Sarah A Scott; Paige E Selvy; Kwangho Kim; Satyawan Jadhav; Ryan D Morrison; J Scott Daniels; H Alex Brown; Craig W Lindsley
Journal:  J Med Chem       Date:  2010-09-23       Impact factor: 7.446

Review 2.  Phospholipase D in brain function and Alzheimer's disease.

Authors:  Tiago Gil Oliveira; Gilbert Di Paolo
Journal:  Biochim Biophys Acta       Date:  2010-04-23

3.  Phospholipase d2 ablation ameliorates Alzheimer's disease-linked synaptic dysfunction and cognitive deficits.

Authors:  Tiago Gil Oliveira; Robin B Chan; Huasong Tian; Mikael Laredo; Guanghou Shui; Agnieszka Staniszewski; Hong Zhang; Lili Wang; Tae-Wan Kim; Karen E Duff; Markus R Wenk; Ottavio Arancio; Gilbert Di Paolo
Journal:  J Neurosci       Date:  2010-12-08       Impact factor: 6.167

4.  Presenilin-1 uses phospholipase D1 as a negative regulator of beta-amyloid formation.

Authors:  Dongming Cai; William J Netzer; Minghao Zhong; Yixin Lin; Guangwei Du; Michael Frohman; David A Foster; Sangram S Sisodia; Huaxi Xu; Fred S Gorelick; Paul Greengard
Journal:  Proc Natl Acad Sci U S A       Date:  2006-01-31       Impact factor: 11.205

5.  Impaired alpha(IIb)beta(3) integrin activation and shear-dependent thrombus formation in mice lacking phospholipase D1.

Authors:  Margitta Elvers; David Stegner; Ina Hagedorn; Christoph Kleinschnitz; Attila Braun; Marijke E J Kuijpers; Michael Boesl; Qin Chen; Johan W M Heemskerk; Guido Stoll; Michael A Frohman; Bernhard Nieswandt
Journal:  Sci Signal       Date:  2010-01-05       Impact factor: 8.192

6.  Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness.

Authors:  Sarah A Scott; Paige E Selvy; Jason R Buck; Hyekyung P Cho; Tracy L Criswell; Ashley L Thomas; Michelle D Armstrong; Carlos L Arteaga; Craig W Lindsley; H Alex Brown
Journal:  Nat Chem Biol       Date:  2009-01-11       Impact factor: 15.040
  6 in total
  10 in total

Review 1.  Chemical modulation of glycerolipid signaling and metabolic pathways.

Authors:  Sarah A Scott; Thomas P Mathews; Pavlina T Ivanova; Craig W Lindsley; H Alex Brown
Journal:  Biochim Biophys Acta       Date:  2014-01-15

Review 2.  Phospholipase D signaling pathways and phosphatidic acid as therapeutic targets in cancer.

Authors:  Ronald C Bruntz; Craig W Lindsley; H Alex Brown
Journal:  Pharmacol Rev       Date:  2014-10       Impact factor: 25.468

3.  Regulation of phospholipase D activity and phosphatidic acid production after purinergic (P2Y6) receptor stimulation.

Authors:  Sarah A Scott; Yun Xiang; Thomas P Mathews; Hyekyung P Cho; David S Myers; Michelle D Armstrong; Keri A Tallman; Matthew C O'Reilly; Craig W Lindsley; H Alex Brown
Journal:  J Biol Chem       Date:  2013-05-30       Impact factor: 5.157

4.  PLD3 in Alzheimer's Disease: a Modest Effect as Revealed by Updated Association and Expression Analyses.

Authors:  Deng-Feng Zhang; Yu Fan; Dong Wang; Rui Bi; Chen Zhang; Yiru Fang; Yong-Gang Yao
Journal:  Mol Neurobiol       Date:  2015-07-21       Impact factor: 5.590

Review 5.  Structure and regulation of human phospholipase D.

Authors:  Forrest Z Bowling; Michael A Frohman; Michael V Airola
Journal:  Adv Biol Regul       Date:  2021-01-03

6.  Phospholipase D inhibitors reduce human prostate cancer cell proliferation and colony formation.

Authors:  Amanda R Noble; Norman J Maitland; Daniel M Berney; Martin G Rumsby
Journal:  Br J Cancer       Date:  2017-11-14       Impact factor: 7.640

Review 7.  Targeting phospholipase D in cancer, infection and neurodegenerative disorders.

Authors:  H Alex Brown; Paul G Thomas; Craig W Lindsley
Journal:  Nat Rev Drug Discov       Date:  2017-02-17       Impact factor: 84.694

8.  Accumulation of minor alleles and risk prediction in schizophrenia.

Authors:  Pei He; Xiaoyun Lei; Dejian Yuan; Zuobin Zhu; Shi Huang
Journal:  Sci Rep       Date:  2017-09-15       Impact factor: 4.379

9.  Enhancement in Phospholipase D Activity as a New Proposed Molecular Mechanism of Haloperidol-Induced Neurotoxicity.

Authors:  Marek Krzystanek; Ewa Krzystanek; Katarzyna Skałacka; Artur Pałasz
Journal:  Int J Mol Sci       Date:  2020-12-04       Impact factor: 5.923

10.  Targeting PLD2 in adipocytes augments adaptive thermogenesis by improving mitochondrial quality and quantity in mice.

Authors:  Hyung Sik Kim; Min Young Park; Nam Joo Yun; Hye Sun Go; Mi Young Kim; Je Kyung Seong; Minyoung Lee; Eun Seok Kang; Jaewang Ghim; Sung Ho Ryu; Brian A Zabel; Ara Koh; Yoe-Sik Bae
Journal:  J Exp Med       Date:  2021-12-23       Impact factor: 17.579
  10 in total

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