Kathleen R Merikangas1, Femke Lamers. 1. Genetic Epidemiology Research Branch, Intramural Research Program, National Institutes of Health, National Institute of Mental Health, Bethesda, Maryland 20892-3720, USA. Kathleen.Merikangas@nih.gov
Abstract
PURPOSE OF REVIEW: Many studies - including meta-analyses - do not distinguish between bipolar I and II disorder. The aim of this study is to review the recent literature on the prevalence, correlates, consequences, and treatment patterns of bipolar II disorder. RECENT FINDINGS: In the past 2 years, several important studies have been conducted in the bipolar II field. The World Mental Health Survey initiative provides us with prevalence rate across 11 countries, while several meta-analyses on suicide and neurocognition directly compared bipolar I with bipolar II, informing us on the severe consequences of bipolar II disorder. Results from studies showed that the lifetime prevalence rate of bipolar II disorder in adults across 11 countries was 0.4%. Rates of bipolar II disorder in prospective studies of adolescents are substantially greater, with lifetime rates approaching 3-4%. SUMMARY: Evidence from these studies regarding comparable clinical consequences, patterns of comorbidity, suicide attempts, family history, and treatment patterns to bipolar I disorder document the validity of the bipolar II subtype.
PURPOSE OF REVIEW: Many studies - including meta-analyses - do not distinguish between bipolar I and II disorder. The aim of this study is to review the recent literature on the prevalence, correlates, consequences, and treatment patterns of bipolar II disorder. RECENT FINDINGS: In the past 2 years, several important studies have been conducted in the bipolar II field. The World Mental Health Survey initiative provides us with prevalence rate across 11 countries, while several meta-analyses on suicide and neurocognition directly compared bipolar I with bipolar II, informing us on the severe consequences of bipolar II disorder. Results from studies showed that the lifetime prevalence rate of bipolar II disorder in adults across 11 countries was 0.4%. Rates of bipolar II disorder in prospective studies of adolescents are substantially greater, with lifetime rates approaching 3-4%. SUMMARY: Evidence from these studies regarding comparable clinical consequences, patterns of comorbidity, suicide attempts, family history, and treatment patterns to bipolar I disorder document the validity of the bipolar II subtype.
Authors: Anne E Rhodes; Michael H Boyle; Jeffrey A Bridge; Mark Sinyor; Paul S Links; Lil Tonmyr; Robin Skinner; Jennifer M Bethell; Corine Carlisle; Sarah Goodday; Travis Salway Hottes; Amanda Newton; Kathryn Bennett; Purnima Sundar; Amy H Cheung; Peter Szatmari Journal: World J Psychiatry Date: 2014-12-22
Authors: G M Goodwin; P M Haddad; I N Ferrier; J K Aronson; Trh Barnes; A Cipriani; D R Coghill; S Fazel; J R Geddes; H Grunze; E A Holmes; O Howes; S Hudson; N Hunt; I Jones; I C Macmillan; H McAllister-Williams; D R Miklowitz; R Morriss; M Munafò; C Paton; B J Saharkian; Kea Saunders; Jma Sinclair; D Taylor; E Vieta; A H Young Journal: J Psychopharmacol Date: 2016-03-15 Impact factor: 4.153
Authors: Ian B Hickie; Jan Scott; Daniel F Hermens; Elizabeth M Scott; Sharon L Naismith; Adam J Guastella; Nick Glozier; Patrick D McGorry Journal: BMC Med Date: 2013-05-14 Impact factor: 8.775