Laura Waters1, Erasmus Smit. 1. Brighton and Sussex University NHS Trust, Lawson Unit, Royal Sussex County Hospital, Brighton, UK. laura.waters@bsuh.nhs.uk
Abstract
PURPOSE OF REVIEW: This review describes the nature and frequency of HIV-1 superinfection and provides advice regarding counselling of patients in accordance with national guidelines. RECENT FINDINGS: Recent studies have demonstrated conflicting results, from no superinfection to an incidence of over 18%. We discuss the difficulties comparing studies due to population and methodological differences. SUMMARY: HIV-infected individuals should be counselled that there is risk of superinfection at all stages of HIV, but this is unlikely to be clinically significant unless transmission of resistance occurs. The risk may be as high as the risk of new incident infection in the presence of on-going exposure.
PURPOSE OF REVIEW: This review describes the nature and frequency of HIV-1 superinfection and provides advice regarding counselling of patients in accordance with national guidelines. RECENT FINDINGS: Recent studies have demonstrated conflicting results, from no superinfection to an incidence of over 18%. We discuss the difficulties comparing studies due to population and methodological differences. SUMMARY:HIV-infected individuals should be counselled that there is risk of superinfection at all stages of HIV, but this is unlikely to be clinically significant unless transmission of resistance occurs. The risk may be as high as the risk of new incident infection in the presence of on-going exposure.
Authors: Fransje A Koning; Anjna Badhan; Simon Shaw; Martin Fisher; Jean L Mbisa; Patricia A Cane Journal: AIDS Res Hum Retroviruses Date: 2013-04-18 Impact factor: 2.205
Authors: Sergio M de Almeida; Michelli F Oliveira; Antoine Chaillon; Indianara Rotta; Clea E Ribeiro; Ana Paula de Pereira; Davey Smith; Scott Letendre; Ronald J Ellis Journal: J Neurovirol Date: 2018-09-07 Impact factor: 2.643
Authors: Cynthia Fair; Lori Wiener; Sima Zadeh; Jamie Albright; Claude Ann Mellins; Michael Mancilla; Vicki Tepper; Connie Trexler; Julia Purdy; Janet Osherow; Susan Lovelace; Suad Kapetanovic Journal: Matern Child Health J Date: 2013-07
Authors: Jeffrey D Fisher; Deborah H Cornman; Paul A Shuper; Sarah Christie; Sandy Pillay; Susan Macdonald; Ntombenhle Ngcobo; K Rivet Amico; Umesh Lalloo; Gerald Friedland; William A Fisher Journal: J Acquir Immune Defic Syndr Date: 2014-12-15 Impact factor: 3.731