BACKGROUND AND PURPOSE: The early detection of poststroke depression is essential for optimizing recovery after stroke. A prospective study was conducted to investigate the diagnostic value of the 9-item and the 2-item Patient Health Questionnaire (PHQ-9, PHQ-2). METHODS: One hundred seventy-one consecutive patients with stroke who could communicate adequately were included. In the 6th to 8th weeks after stroke, depression was measured using the PHQ-9 and PHQ-2 and diagnosed using the Composite International Diagnostic Interview. RESULTS: Of the participating patients, 20 (12.2%) were depressed. The PHQ-9 performed best at a score ≥10, a sensitivity of 0.80 (95% CI, 0.62-0.98), and a specificity of 0.78 (95% CI, 0.72-0.85) and the PHQ-2 at a score ≥2 with a sensitivity of 0.75 (95% CI, 0.56-0.94) and a specificity of 0.76 (95% CI, 0.69-0.83). Administering the PHQ-9 only to patients who scored ≥2 on the PHQ-2 improved the identification of depression (sensitivity, 0.87; 95% CI, 0.69-1.04). CONCLUSIONS: The diagnostic value is acceptable to good for PHQ-9 scores ≥10 and PHQ-2 scores ≥2. Conducting a PHQ-9 only in patients with a PHQ-2 score ≥2 generates the best results.
BACKGROUND AND PURPOSE: The early detection of poststroke depression is essential for optimizing recovery after stroke. A prospective study was conducted to investigate the diagnostic value of the 9-item and the 2-item Patient Health Questionnaire (PHQ-9, PHQ-2). METHODS: One hundred seventy-one consecutive patients with stroke who could communicate adequately were included. In the 6th to 8th weeks after stroke, depression was measured using the PHQ-9 and PHQ-2 and diagnosed using the Composite International Diagnostic Interview. RESULTS: Of the participating patients, 20 (12.2%) were depressed. The PHQ-9 performed best at a score ≥10, a sensitivity of 0.80 (95% CI, 0.62-0.98), and a specificity of 0.78 (95% CI, 0.72-0.85) and the PHQ-2 at a score ≥2 with a sensitivity of 0.75 (95% CI, 0.56-0.94) and a specificity of 0.76 (95% CI, 0.69-0.83). Administering the PHQ-9 only to patients who scored ≥2 on the PHQ-2 improved the identification of depression (sensitivity, 0.87; 95% CI, 0.69-1.04). CONCLUSIONS: The diagnostic value is acceptable to good for PHQ-9 scores ≥10 and PHQ-2 scores ≥2. Conducting a PHQ-9 only in patients with a PHQ-2 score ≥2 generates the best results.
Authors: Laura Mussulman; Edward F Ellerbeck; A Paula Cupertino; Kristopher J Preacher; Ryan Spaulding; Delwyn Catley; Lisa Sanderson Cox; Leah Lambart; Jamie J Hunt; Niaman Nazir; Theresa Shireman; Kimber P Richter Journal: Contemp Clin Trials Date: 2014-04-24 Impact factor: 2.226
Authors: Julia M P Poritz; Joseph Mignogna; Aimee J Christie; Sally A Holmes; Herb Ames Journal: J Spinal Cord Med Date: 2017-03-29 Impact factor: 1.985
Authors: Rahul R Karamchandani; Farhaan Vahidy; Suhas Bajgur; Kim Yen Thi Vu; H Alex Choi; Robert Kirk Hamilton; Mohammad H Rahbar; Sean I Savitz Journal: PLoS One Date: 2015-06-03 Impact factor: 3.240
Authors: Julianne Vermeer; Amanda McIntyre; Shannon Janzen; Danielle Rice; Laura Allen; David Ure; Robert Teasell Journal: Neurol Res Int Date: 2018-04-11
Authors: Janneke M de Man-van Ginkel; Thóra B Hafsteinsdóttir; Eline Lindeman; Mirjam I Geerlings; Diederick E Grobbee; Marieke J Schuurmans Journal: PLoS One Date: 2015-12-04 Impact factor: 3.240